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Your query returned 9 entries. Printable version
EC | 2.7.1.127 | ||||||||||||||
Accepted name: | inositol-trisphosphate 3-kinase | ||||||||||||||
Reaction: | ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | ||||||||||||||
For diagram of myo-inositol-phosphate biosynthesis, click here | |||||||||||||||
Other name(s): | 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase | ||||||||||||||
Systematic name: | ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase | ||||||||||||||
Comments: | Activated by Ca2+. Three isoforms have been shown to exist [3]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 106283-10-7 | ||||||||||||||
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EC | 2.7.1.134 | ||||||||||||||
Accepted name: | inositol-tetrakisphosphate 1-kinase | ||||||||||||||
Reaction: | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | ||||||||||||||
For diagram of myo-inositol-phosphate biosynthesis, click here | |||||||||||||||
Other name(s): | 1D-myo-inositol-tetrakisphosphate 1-kinase; inositol-trisphosphate 6-kinase; 1D-myo-inositol-trisphosphate 6-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase; inositol-trisphosphate 5-kinase; 1D-myo-inositol-trisphosphate 5-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase | ||||||||||||||
Systematic name: | ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase | ||||||||||||||
Comments: | This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. The enzymes from animals and plants also have the activity of EC 2.7.1.159, inositol-1,3,4-trisphosphate 5/6-kinase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 187175-98-0 | ||||||||||||||
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EC | 2.7.1.159 | ||||||||||||||
Accepted name: | inositol-1,3,4-trisphosphate 5/6-kinase | ||||||||||||||
Reaction: | (1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate |
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Other name(s): | Ins(1,3,4)P3 5/6-kinase; inositol trisphosphate 5/6-kinase | ||||||||||||||
Systematic name: | ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase | ||||||||||||||
Comments: | In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 288307-53-9 | ||||||||||||||
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EC | 3.1.3.36 | ||||||||||||||
Accepted name: | phosphoinositide 5-phosphatase | ||||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | ||||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate = PtdIns(1,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate = PtdIns(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate = PtdIns(1,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | type II inositol polyphosphate 5-phosphatase; triphosphoinositide phosphatase; IP3 phosphatase; PtdIns(4,5)P2 phosphatase; triphosphoinositide phosphomonoesterase; diphosphoinositide phosphatase; inositol 1,4,5-triphosphate 5-phosphomonoesterase; inositol triphosphate 5-phosphomonoesterase; phosphatidylinositol-bisphosphatase; phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphatase; polyphosphoinositol lipid 5-phosphatase; phosphatidyl-inositol-bisphosphate phosphatase | ||||||||||||||
Systematic name: | phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||||||||
Comments: | These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9036-01-5 | ||||||||||||||
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EC | 3.1.3.56 | ||||||||||||||
Accepted name: | inositol-polyphosphate 5-phosphatase | ||||||||||||||
Reaction: | (1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate |
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For diagram of myo-inositol-phosphate biosynthesis, click here | |||||||||||||||
Other name(s): | type I inositol-polyphosphate phosphatase; inositol trisphosphate phosphomonoesterase; InsP3/Ins(1,3,4,5)P4 5-phosphatase; inosine triphosphatase; D-myo-inositol 1,4,5-triphosphate 5-phosphatase; D-myo-inositol 1,4,5-trisphosphate 5-phosphatase; L-myo-inositol 1,4,5-trisphosphate-monoesterase; inositol phosphate 5-phosphomonoesterase; inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase; Ins(1,4,5)P3 5-phosphatase; D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase; inositol 1,4,5-trisphosphate phosphatase; inositol polyphosphate-5-phosphatase; myo-inositol-1,4,5-trisphosphate 5-phosphatase; inositol-1,4,5-trisphosphate 5-phosphatase | ||||||||||||||
Systematic name: | 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase | ||||||||||||||
Comments: | One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 106283-14-1 | ||||||||||||||
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EC | 3.1.3.57 | ||||||||||||||
Accepted name: | inositol-1,4-bisphosphate 1-phosphatase | ||||||||||||||
Reaction: | 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate | ||||||||||||||
For diagram of myo-inositol-phosphate biosynthesis, click here | |||||||||||||||
Other name(s): | inositol-polyphosphate 1-phosphatase | ||||||||||||||
Systematic name: | 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase | ||||||||||||||
Comments: | The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 111070-17-8, 111694-13-4 | ||||||||||||||
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EC | 3.1.3.62 | ||||||||||||||
Accepted name: | multiple inositol-polyphosphate phosphatase | ||||||||||||||
Reaction: | (1) myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate (2) 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate (3) 1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate (4) 1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate (5) 1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate |
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Glossary: | myo-inositol hexakisphosphate = phytate 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = Ins(1,3,4,5,6)P5 1D-myo-inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4 1D-myo-inositol 1,4,5,6-tetrakisphosphate = Ins(1,4,5,6)P4 1D-myo-inositol 1,4,5-trisphosphate = Ins(1,4,5)P3 1D-myo-inositol 2,3-bisphosphate = Ins(2,3)P2 1D-myo-inositol 2-phosphate = Ins(2)P |
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Other name(s): | MIPP; phytase (ambiguous); 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase (incorrect) | ||||||||||||||
Systematic name: | myo-inositol-hexakisphosphate phosphohydrolase | ||||||||||||||
Comments: | This ubiquitous enzyme degrades myo-inositol hexakisphosphate (phytate) to Ins(2,3)P2 and Ins(2)P. Activities have been characterized in the yeast Saccharomyces cerevisiae [2], the plant Lupinus albus [3] and the bacteria Bacillus sp. [4] and Raoultella terrigena [5]. In mammal cells Ins(2,3)P2 and Ins(2)P are the major inositol phosphate compounds found [6]. The mammal enzyme is also active on Ins(1,3,4,5,6)P5 that is dephosphorylated to Ins(1,4,5,6)P4 and Ins(1,4,5)P3, and on 2,3-bisphospho-D-glycerate (cf. EC 3.1.3.80, 2,3-bisphosphoglycerate 3-phosphatase). In addition, it acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3 in vitro (cf. EC 3.1.3.67, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) [7]. It does not hydrolyse phosphates from the 2-positions of inositol phosphates [6]. In other organisms the degradation of phytate follows different routes. (cf. EC 3.1.3.8, 3-phytase, EC 3.1.3.26, 4-phytase, and EC 3.1.3.72, 5-phytase). | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 116958-30-6 | ||||||||||||||
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EC | 3.1.3.67 | ||||||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | ||||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | ||||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||||
Glossary: | inositol 1,4,5-trisphosphate = Ins(1,4,5)P3 inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | PTEN (gene name); MMAC1 (gene name); phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase | ||||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase | ||||||||||||||
Comments: | Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3 | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 210488-47-4 | ||||||||||||||
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EC | 3.1.3.86 | ||||||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | ||||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | ||||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-trisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | SHIP1; SHIP2; SHIP; p150Ship | ||||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase | ||||||||||||||
Comments: | This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
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