EC |
1.1.1.416 |
Accepted name: |
isopyridoxal dehydrogenase (5-pyridoxolactone-forming) |
Reaction: |
isopyridoxal + NAD+ = 5-pyridoxolactone + NADH + H+ |
Glossary: |
isopyridoxal = 5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carbaldehyde
5-pyridoxolactone = 7-hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one |
Systematic name: |
isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming) |
Comments: |
The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936] |
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[EC 1.1.1.416 created 2018] |
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EC |
1.1.3.12 |
Accepted name: |
pyridoxine 4-oxidase |
Reaction: |
pyridoxine + O2 = pyridoxal + H2O2 |
Other name(s): |
pyridoxin 4-oxidase; pyridoxol 4-oxidase |
Systematic name: |
pyridoxine:oxygen 4-oxidoreductase |
Comments: |
A flavoprotein. Can also use 2,6-dichloroindophenol as an acceptor. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37250-82-1 |
References: |
1. |
Sundaram, T.K. and Snell, E.E. The bacterial oxidation of vitamin B6. V. The enzymatic formation of pyridoxal and isopyridoxal from pyridoxine. J. Biol. Chem. 244 (1969) 2577–2584. [PMID: 5769992] |
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[EC 1.1.3.12 created 1972, modified 1976] |
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EC |
1.1.99.9 |
Accepted name: |
pyridoxine 5-dehydrogenase |
Reaction: |
pyridoxine + acceptor = isopyridoxal + reduced acceptor |
Other name(s): |
pyridoxal-5-dehydrogenase; pyridoxol 5-dehydrogenase; pyridoxin 5-dehydrogenase; pyridoxine dehydrogenase; pyridoxine 5′-dehydrogenase; pyridoxine:(acceptor) 5-oxidoreductase |
Systematic name: |
pyridoxine:acceptor 5-oxidoreductase |
Comments: |
A flavoprotein (FAD). |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 9023-39-6 |
References: |
1. |
Sundaram, T.K. and Snell, E.E. The bacterial oxidation of vitamin B6. V. The enzymatic formation of pyridoxal and isopyridoxal from pyridoxine. J. Biol. Chem. 244 (1969) 2577–2584. [PMID: 5769992] |
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[EC 1.1.99.9 created 1972, modified 1976] |
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EC |
1.2.1.100 |
Accepted name: |
5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase |
Reaction: |
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ |
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For diagram of pyridoxal catabolism, click here |
Other name(s): |
mlr6793 (locus name) |
Systematic name: |
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase |
Comments: |
The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936] |
2. |
Yokochi, N., Yoshikane, Y., Matsumoto, S., Fujisawa, M., Ohnishi, K. and Yagi, T. Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase. J. Biochem. 145 (2009) 493–503. [DOI] [PMID: 19218190] |
3. |
Mugo, A.N., Kobayashi, J., Mikami, B., Yoshikane, Y., Yagi, T. and Ohnishi, K. Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD(+)-dependent dismutase from Mesorhizobium loti. Biochem. Biophys. Res. Commun. 456 (2015) 35–40. [DOI] [PMID: 25446130] |
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[EC 1.2.1.100 created 2018] |
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EC |
1.2.1.102 |
Accepted name: |
isopyridoxal dehydrogenase (5-pyridoxate-forming) |
Reaction: |
isopyridoxal + NAD+ + H2O = 5-pyridoxate + NADH + H+ |
Glossary: |
isopyridoxal = 5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carbaldehyde
5-pyridoxate = 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate |
Systematic name: |
isopyridoxal:NAD+ oxidoreductase (5-pyridoxate-forming) |
Comments: |
The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.1.1.416, isopyridoxal dehydrogenase (5-pyridoxolactone-forming). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936] |
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[EC 1.2.1.102 created 2018] |
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