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1.14.13.171

Accepted name:

neopentalenolactone D synthase

Reaction:

1-deoxy-11-oxopentalenate + NADPH + H⁺ + O₂ = neopentalenolactone D + NADP⁺ + H₂O

For diagram of pentalenolactone biosynthesis, click here

Glossary:

1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate
neopentalenolactone D = (1S,4aR,6aS)-1,7,7-trimethyl-3-oxo-4,4a,6a,7,8,9-hexahydro-3H-pentaleno[6a,1-c]pyran-5-carboxylate

Other name(s):

ptlE (gene name)

Systematic name:

1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D-forming)

Comments:

A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Seo, M.J., Zhu, D., Endo, S., Ikeda, H. and Cane, D.E. Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone. Biochemistry 50 (2011) 1739–1754. [DOI] [PMID: 21250661]

[EC 1.14.13.171 created 2012]