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Your query returned 11 entries. Printable version
EC | 1.1.1.340 | ||||||||||||
Accepted name: | 1-deoxy-11β-hydroxypentalenate dehydrogenase | ||||||||||||
Reaction: | 1-deoxy-11β-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ | ||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | 1-deoxy-11β-hydroxypentalenate = (1S,2R,3aR,5aS,8aR)-2-hydroxy-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate 1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate |
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Other name(s): | 1-deoxy-11β-hydroxypentalenic acid dehydrogenase; ptlF (gene name); penF (gene name) | ||||||||||||
Systematic name: | 1-deoxy-11β-hydroxypentalenate:NAD+ oxidoreductase | ||||||||||||
Comments: | Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 1.3.7.10 | ||||||||||||
Transferred entry: | pentalenolactone synthase. Now EC 1.14.19.8, pentalenolactone synthase | ||||||||||||
EC | 1.14.11.35 | ||||||||||||
Accepted name: | 1-deoxypentalenic acid 11β-hydroxylase | ||||||||||||
Reaction: | 1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11β-hydroxypentalenate + succinate + CO2 | ||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | 1-deoxypentalenate = (1R,3aR,5aS,8aR)-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate 1-deoxy-11β-hydroxypentalenate = (1S,2R,3aR,5aS,8aR)-2-hydroxy-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate |
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Other name(s): | ptlH (gene name); sav2991 (gene name); pntH (gene name) | ||||||||||||
Systematic name: | 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase | ||||||||||||
Comments: | The enzyme requires iron(II) and ascorbate. Isolated from the bacterium Streptomyces avermitilis. Part of the pathway for pentalenolactone biosynthesis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 1.14.11.36 | ||||||||||||
Accepted name: | pentalenolactone F synthase | ||||||||||||
Reaction: | pentalenolactone D + 2 2-oxoglutarate + 2 O2 = pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction) (1a) pentalenolactone D + 2-oxoglutarate + O2 = pentalenolactone E + succinate + CO2 + H2O (1b) pentalenolactone E + 2-oxoglutarate + O2 = pentalenolactone F + succinate + CO2 |
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For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | pentalenolactone D = (1S,4aR,6aS,9aR)-1,8,8-trimethyl-2-oxo-1,2,4,4a,6a,7,8,9-octahydropentaleno[1,6a-c]pyran-5-carboxylate pentalenolactone E = (4aR,6aS,9aR)-8,8-dimethyl-1-methylene-2-oxo-1,2,4,4a,6a,7,8,9-octahydropentaleno[1,6a-c]pyran-5-carboxylate pentalenolactone F = (1′R,4′aR,6′aS,9′aR)-8′,8′-dimethyl-2′-oxo-4′,4′a,6′a,8′,9′-hexahydrospiro[oxirane-2,1′-pentaleno[1,6a-c]pyran]-5′-carboxylic acid |
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Other name(s): | penD (gene name); pntD (gene name); ptlD (gene name) | ||||||||||||
Systematic name: | pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase | ||||||||||||
Comments: | Requires iron(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 1.14.13.133 | ||||||||||||
Transferred entry: | pentalenene oxygenase. Now EC 1.14.15.32, pentalenene oxygenase | ||||||||||||
EC | 1.14.13.170 | ||||||||||||
Accepted name: | pentalenolactone D synthase | ||||||||||||
Reaction: | 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = pentalenolactone D + NADP+ + H2O | ||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | 1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate pentalenolactone D = (1S,4aR,6aS,9aR)-1,8,8-trimethyl-2-oxo-1,2,4,4a,6a,7,8,9-octahydropentaleno[1,6a-c]pyran-5-carboxylate |
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Other name(s): | penE (gene name); pntE (gene name) | ||||||||||||
Systematic name: | 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D-forming) | ||||||||||||
Comments: | A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 1.14.13.171 | ||||||||||||
Accepted name: | neopentalenolactone D synthase | ||||||||||||
Reaction: | 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = neopentalenolactone D + NADP+ + H2O | ||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | 1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate neopentalenolactone D = (1S,4aR,6aS)-1,7,7-trimethyl-3-oxo-4,4a,6a,7,8,9-hexahydro-3H-pentaleno[6a,1-c]pyran-5-carboxylate |
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Other name(s): | ptlE (gene name) | ||||||||||||
Systematic name: | 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D-forming) | ||||||||||||
Comments: | A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 1.14.15.11 | ||||||||||||
Accepted name: | pentalenic acid synthase | ||||||||||||
Reaction: | 1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O | ||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | 1-deoxypentalenate = (1R,3aR,5aS,8aR)-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate pentalenate = (1R,3aR,5aS,6R,8aS)-6-hydroxy-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate |
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Other name(s): | CYP105D7; sav7469 (gene name); 1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase | ||||||||||||
Systematic name: | 1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase | ||||||||||||
Comments: | A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 1.14.15.32 | ||||||||||||
Accepted name: | pentalenene oxygenase | ||||||||||||
Reaction: | pentalenene + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ + 2 O2 = pentalen-13-al + 4 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O (overall reaction) (1a) pentalenene + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = pentalen-13-ol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O (1b) pentalen-13-ol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = pentalen-13-al + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O |
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For diagram of humulene-based sequiterpenoid biosynthesis, click here | |||||||||||||
Other name(s): | PtlI | ||||||||||||
Systematic name: | pentalenene,reduced ferredoxin:oxygen 13-oxidoreductase | ||||||||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein found in the bacterium Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 1.14.19.8 | ||||||||||||
Accepted name: | pentalenolactone synthase | ||||||||||||
Reaction: | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O | ||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||
Glossary: | pentalenolactone F = (1R,4aR,6aS,9aR)-8,8-dimethyl-2-oxo-4,4a,6a,8,9-hexahydrospiro[oxirane-2,1-pentaleno[1,6a-c]pyran]-5-carboxylic acid pentalenolactone = (1R,4aR,6aR,7S,9aS)-7,8-dimethyl-2-oxo-4,4a,6a,7-tetrahydrospiro[oxirane-2,1-pentaleno[1,6a-c]pyran]-5-carboxylic acid |
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Other name(s): | penM (gene name); pntM (gene name) | ||||||||||||
Systematic name: | pentalenolactone-reduced-ferredoxin:oxygen oxidoreductase (pentalenolactone-forming) | ||||||||||||
Comments: | A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 4.2.3.7 | ||||||||||||
Accepted name: | pentalenene synthase | ||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate = pentalenene + diphosphate | ||||||||||||
For diagram of sesquiterpenoid biosynthesis based on humulene, click here | |||||||||||||
Glossary: | pentalenene = (1R,8aR)-1,4,7,7-tetramethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene | ||||||||||||
Other name(s): | pentalenene synthetase | ||||||||||||
Systematic name: | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming) | ||||||||||||
Comments: | Isolated from Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. The 9si hydrogen of farnesyl diphosphate undergoes a 1,2-hydride shift where it becomes the 1α hydrogen of pentalenene. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 90597-46-9 | ||||||||||||
References: |
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