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Your query returned 5 entries. Printable version
EC | 1.3.1.117 | ||||||||||||
Accepted name: | hydroxycinnamoyl-CoA reductase | ||||||||||||
Reaction: | (1) dihydro-4-coumaroyl-CoA + NADP+ = trans-4-coumaroyl-CoA + NADPH + H+ (2) dihydroferuloyl-CoA + NADP+ = trans-feruloyl-CoA + NADPH + H+ |
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For diagram of phloretin biosynthesis, click here | |||||||||||||
Glossary: | trans-4-coumaroyl-CoA = (E)-3-(4-hydroxyphenyl)prop-2-enoyl-CoA trans-feruloyl-CoA = (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl-CoA dihydro-4-coumaroyl-CoA = 3-(4-hydroxyphenyl)propanoyl-CoA dihydroferuloyl-CoA = 3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA |
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Other name(s): | MdHCDBR; hydroxycinnamoyl-CoA double bond reductase | ||||||||||||
Systematic name: | dihydro-4-coumaroyl-CoA:NADP+ 2,3-oxidoreductase | ||||||||||||
Comments: | Isolated from Malus X domestica (apple). Involved in dihydrochalcone biosynthesis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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EC | 2.3.1.74 | ||||||||||||
Accepted name: | chalcone synthase | ||||||||||||
Reaction: | 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 | ||||||||||||
For diagram of chalcone and stilbene biosynthesis, click here | |||||||||||||
Glossary: | phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one | ||||||||||||
Other name(s): | naringenin-chalcone synthase; flavanone synthase; 6′-deoxychalcone synthase; chalcone synthetase; DOCS; CHS | ||||||||||||
Systematic name: | malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) | ||||||||||||
Comments: | The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56803-04-4 | ||||||||||||
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EC | 2.4.1.357 | ||||||||||||
Accepted name: | phlorizin synthase | ||||||||||||
Reaction: | UDP-α-D-glucose + phloretin = UDP + phlorizin | ||||||||||||
For diagram of phloretin biosynthesis, click here | |||||||||||||
Glossary: | phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one phlorizin = 3-(4-hydroxyphenyl)-1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]propan-1-one |
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Other name(s): | MdPGT1: P2’GT | ||||||||||||
Systematic name: | UDP-α-D-glucose:phloretin 2′-O-D-glucosyltransferase | ||||||||||||
Comments: | Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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EC | 3.2.1.62 | ||||||||||||
Accepted name: | glycosylceramidase | ||||||||||||
Reaction: | (1) a β-D-glucosyl-N-acylsphingosine + H2O = a ceramide + β-D-glucose (2) a β-D-galactosyl-N-acylsphingosine + H2O = a ceramide + β-D-galactose (3) a flavonoid-O-β-D-glucoside + H2O = a flavonoid + β-D-glucose |
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For diagram of phloretin biosynthesis, click here and for diagram of glycolipid biosynthesis, click here | |||||||||||||
Glossary: | a ceramide = an N-acylsphingosine | ||||||||||||
Other name(s): | phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin β-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase; LPH (gene name); LCT (gene name); glycosyl-N-acylsphingosine glycohydrolase | ||||||||||||
Systematic name: | β-D-glucosyl-N-acylsphingosine glycohydrolase (configuration-retaining) | ||||||||||||
Comments: | The enzyme, found in the intestinal mucosa, hydrolyses β-D-glucosyl and β-D-galactosyl residues from a very broad range of substrates using a retaining mechanism. Characterized substrates include glucosyl- and galactosyl-ceramides [3], O3-, O4′ and O7-glucosylated flavonoids [6], and the 2′-O-glucosylated dihydrochalcone phlorizin [1]. The enzyme includes two glycosyl hydrolase domains, both belonging to the GH1 family. While one domain is responsible for the activity described here, the other catalyses the reaction of EC 3.2.1.108, lactase [4,5]. cf. EC 3.2.1.45, glucosylceramidase and EC 3.2.1.46, galactosylceramidase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-10-7 | ||||||||||||
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EC | 3.7.1.4 | ||||||||||||
Accepted name: | phloretin hydrolase | ||||||||||||
Reaction: | phloretin + H2O = phloretate + phloroglucinol | ||||||||||||
For diagram of phloretin biosynthesis, click here | |||||||||||||
Glossary: | phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one phloretate = 3-(4-hydroxyphenyl)propanoate phloroglucinol = benzene-1,3,5-triol |
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Other name(s): | ErPhy; lactase-phlorerin hydrolase; C-acylphenol hydrolase; 2′,4,4′,6′-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase (incorrect) | ||||||||||||
Systematic name: | phloretin acylhydrolase (phloroglucinol-forming) | ||||||||||||
Comments: | Also hydrolyses other C-acylated phenols related to phloretin. Isolated from the fungus Aspergillus niger and the bacteria Pantoea agglomerans and Eubacterium ramulus. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37289-38-6 | ||||||||||||
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