The Enzyme Database

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Accepted name: pseudolaratriene synthase
Reaction: geranylgeranyl diphosphate = pseudolaratriene + diphosphate
For diagram of miscellaneous diterpenoid biosynthesis, click here
Glossary: pseudolaradiene = (1RS,3aSR,8aRS)-3a,6-dimethyl-1-(6-methylhepta-2,5-dien-2-yl)-1,2,3,3a,4,7,8,8a-octahydrohydroazulene
Other name(s): PxaTPS8
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, pseudolaradiene-forming)
Comments: Isolated from the plant Pseudolarix amabilis (golden larch). The product is oxidized to pseudolaric acid B, a microtubule-destabilizing agent.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Mafu, S., Karunanithi, P.S., Palazzo, T.A., Harrod, B.L., Rodriguez, S.M., Mollhoff, I.N., O'Brien, T.E., Tong, S., Fiehn, O., Tantillo, D.J., Bohlmann, J. and Zerbe, P. Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase. Proc. Natl. Acad. Sci. USA 114 (2017) 974–979. [DOI] [PMID: 28096378]
[EC created 2017]

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