The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 2.7.1.228     
Accepted name: mannosyl-inositol-phosphoceramide inositolphosphotransferase
Reaction: 1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2′R)-2′-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2′R)-2′-hydroxyphytoceramide
Glossary: a very-long-chain mannosyl-diphosphoinositol-(2′R)-2′-hydroxyphytoceramide = a very-long-chain mannosyl-diphosphoinositol-α-hydroxyphytoceramide = MIP2C
Other name(s): IPT1 (gene name)
Systematic name: 1-phosphatidyl-1D-myo-inositol:mannosylinositol phospho-(2′R)-2′-hydroxyphytoceramide phosphoinositoltransferase
Comments: This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-α-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Dickson, R.C., Nagiec, E.E., Wells, G.B., Nagiec, M.M. and Lester, R.L. Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J. Biol. Chem. 272 (1997) 29620–29625. [PMID: 9368028]
[EC 2.7.1.228 created 2019]
 
 


Data © 2001–2020 IUBMB
Web site © 2005–2020 Andrew McDonald