The Enzyme Database

Table of Contents

The enzymes in this section of the database are organized as you would find them in the Enzyme-Nomenclature book. Click [+] to expand, and [–] to collapse, any section. Clicking on a heading will open a popup window with information on that class, subclass or sub-subclass.

For a fully expanded list of the classes, subclasses and sub-subclasses, click here

[+subclass]. [+sub-subclass]. [+serial]

EC 1 []   
    EC 1.1  [+]      
    EC 1.2  [+]      
    EC 1.3  [+]      
    EC 1.4  [+]      
    EC 1.5  [+]      
    EC 1.6  [+]      
    EC 1.7  [+]      
    EC 1.8  [+]      
    EC 1.9  [+]      
    EC 1.10  [+]      
    EC 1.11  [+]      
    EC 1.12  [+]      
    EC 1.13  [+]      
    EC 1.14  []      
        EC 1.14.1       [+]    With NADH or NADPH as one donor (deleted sub-subclass) 
        EC 1.14.2       [+]    With ascorbate as one donor (deleted sub-subclass) 
        EC 1.14.3       [+]    With reduced pteridine as one donor (deleted sub-subclass) 
        EC 1.14.11       [+]    With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor 
        EC 1.14.12       [+]    With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor 
        EC 1.14.13       []    With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor 
                EC                      salicylate 1-monooxygenase 
                EC                      4-hydroxybenzoate 3-monooxygenase 
                EC                      4-hydroxyphenylacetate 3-monooxygenase. Now EC, 4-hydroxyphenylacetate 3-monooxygenase. 
                EC                      melilotate 3-monooxygenase 
                EC                      imidazoleacetate 4-monooxygenase 
                EC                      orcinol 2-monooxygenase 
                EC                      phenol 2-monooxygenase (NADPH) 
                EC                      flavin-containing monooxygenase 
                EC                      kynurenine 3-monooxygenase 
                EC                      2,6-dihydroxypyridine 3-monooxygenase 
                EC                      trans-cinnamate 4-monooxygenase. Now EC, trans-cinnamate 4-monooxygenase 
                EC                      benzoate 4-monooxygenase. Now EC, benzoate 4-monooxygenase 
                EC                      calcidiol 1-monooxygenase. Now classified as EC, calcidiol 1-monooxygenase 
                EC                      trans-cinnamate 2-monooxygenase 
                EC                      cholestanetriol 26-monooxygenase. Now EC, cholestanetriol 26-monooxygenase. 
                EC                      cyclopentanone monooxygenase 
                EC                      cholesterol 7α-monooxygenase. Now EC, cholesterol 7α-monooxygenase 
                EC                      4-hydroxyphenylacetate 1-monooxygenase 
                EC                      taxifolin 8-monooxygenase 
                EC                      2,4-dichlorophenol 6-monooxygenase 
                EC                      flavonoid 3′-monooxygenase. Now EC, flavonoid 3′-monooxygenase. 
                EC                      cyclohexanone monooxygenase 
                EC                      3-hydroxybenzoate 4-monooxygenase 
                EC                      3-hydroxybenzoate 6-monooxygenase 
                EC                      methane monooxygenase (soluble) 
                EC                      phosphatidylcholine 12-monooxygenase. Now classified as EC, phosphatidylcholine 12-monooxygenase. 
                EC                      4-aminobenzoate 1-monooxygenase 
                EC                      3,9-dihydroxypterocarpan 6a-monooxygenase. Now EC, 3,9-dihydroxypterocarpan 6a-monooxygenase 
                EC                      4-nitrophenol 2-monooxygenase 
                EC                      leukotriene-B4 20-monooxygenase. Now EC, leukotriene-B4 20-monooxygenase 
                EC                      2-nitrophenol 2-monooxygenase 
                EC                      albendazole monooxygenase 
                EC                      4-hydroxybenzoate 3-monooxygenase [NAD(P)H] 
                EC                      leukotriene-E4 20-monooxygenase 
                EC                      anthranilate 3-monooxygenase (deaminating) 
                EC                      5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase. Now EC, 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase 
                EC                      methyltetrahydroprotoberberine 14-monooxygenase. Now EC, methyltetrahydroprotoberberine 14-monooxygenase 
                EC                      anhydrotetracycline 6-monooxygenase 
                EC                      nitric-oxide synthase (NADPH) 
                EC                      anthraniloyl-CoA monooxygenase 
                EC                      tyrosine N-monooxygenase. Now EC, tyrosine N-monooxygenase 
                EC                      hydroxyphenylacetonitrile 2-monooxygenase. The activity is covered by EC, 4-hydroxyphenylacetaldehyde oxime monooxygenase, that performs the two consecutive reactions in the conversion of (Z)-4-hydroxyphenylacetaldehyde oxime to (S)-4-hydroxymandelonitrile 
                EC                      questin monooxygenase 
                EC                      2-hydroxybiphenyl 3-monooxygenase 
                EC                      CMP-N-acetylneuraminate monooxygenase. Now EC, CMP-N-acetylneuraminate monooxygenase 
                EC                      (-)-menthol monooxygenase 
                EC                      (S)-limonene 3-monooxygenase. Now EC, (S)-limonene 3-monooxygenase 
                EC                      (S)-limonene 6-monooxygenase. Now classified as EC, (S)-limonene 6-monooxygenase 
                EC                      (S)-limonene 7-monooxygenase. Now classified as EC, (S)-limonene 7-monooxygenase 
                EC                      pentachlorophenol monooxygenase 
                EC                      6-oxocineole dehydrogenase 
                EC                      isoflavone 3′-hydroxylase. Now EC, isoflavone 3′-hydroxylase 
                EC                      4′-methoxyisoflavone 2′-hydroxylase. Now EC, 4′-methoxyisoflavone 2′-hydroxylase 
                EC                      ketosteroid monooxygenase 
                EC                      protopine 6-monooxygenase. Now EC, protopine 6-monooxygenase 
                EC                      dihydrosanguinarine 10-monooxygenase. Now EC, dihydrosanguinarine 10-monooxygenase 
                EC                      dihydrochelirubine 12-monooxygenase. Now EC, dihydrochelirubine 12-monooxygenase 
                EC                      benzoyl-CoA 3-monooxygenase 
                EC                      L-lysine N6-monooxygenase (NADPH) 
                EC                      27-hydroxycholesterol 7α-monooxygenase. Now classified as EC, 25/26-hydroxycholesterol 7α-hydroxylase 
                EC                      2-hydroxyquinoline 8-monooxygenase 
                EC                      4-hydroxyquinoline 3-monooxygenase 
                EC                      3-hydroxyphenylacetate 6-hydroxylase 
                EC                      4-hydroxybenzoate 1-hydroxylase 
                EC                       2-hydroxyquinoline 8-monooxygenase 
                EC                      2-hydroxycyclohexanone 2-monooxygenase 
                EC                      quinine 3-monooxygenase. Now EC, quinine 3-monooxygenase 
                EC                      4-hydroxyphenylacetaldehyde oxime monooxygenase. Now EC, 4-hydroxyphenylacetaldehyde oxime monooxygenase 
                EC                      alkene monooxygenase 
                EC                      sterol 14α-demethylase. Now EC, sterol 14α-demethylase 
                EC                      N-methylcoclaurine 3′-monooxygenase. Now EC, N-methylcoclaurine 3′-monooxygenase 
                EC                      methylsterol monooxygenase. Now classified as EC, methylsterol monooxygenase 
                EC                      tabersonine 16-hydroxylase. Now EC, tabersonine 16-hydroxylase 
                EC                      7-deoxyloganin 7-hydroxylase. Now EC, 7-deoxyloganin 7-hydroxylase 
                EC                      vinorine hydroxylase. Now EC, vinorine hydroxylase 
                EC                      taxane 10β-hydroxylase. Now EC, taxane 10β-hydroxylase 
                EC                      taxane 13α-hydroxylase. Now EC, taxane 13α-hydroxylase 
                EC                      ent-kaurene oxidase. Now EC, ent-kaurene monooxygenase 
                EC                      ent-kaurenoic acid oxidase. Now EC, ent-kaurenoic acid oxidase 
                EC                      (R)-limonene 6-monooxygenase. Now classified as EC, (R)-limonene 6-monooxygenase 
                EC                      magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase 
                EC                      vanillate monooxygenase 
                EC                      precorrin-3B synthase 
                EC                      4-hydroxyacetophenone monooxygenase 
                EC                      glyceollin synthase. Now EC, glyceollin synthase 
                EC                      2-hydroxyisoflavanone synthase. This enzyme was classified on the basis of an incorrect reaction. The activity is covered by EC, 2-hydroxyisoflavanone synthase 
                EC                      licodione synthase. Now EC, licodione synthase 
                EC                      flavanoid 3,5-hydroxylase. Now EC, flavanoid 3,5-hydroxylase 
                EC                      isoflavone 2-hydroxylase. Now EC, isoflavone 2-hydroxylase 
                EC                      zeaxanthin epoxidase. Now EC, zeaxanthin epoxidase 
                EC                      deoxysarpagine hydroxylase. Now EC, deoxysarpagine hydroxylase 
                EC                      phenylacetone monooxygenase 
                EC                      (+)-abscisic acid 8-hydroxylase. Now EC, (+)-abscisic acid 8-hydroxylase 
                EC                      lithocholate 6β-hydroxylase. Now EC, lithocholate 6β-hydroxylase 
                EC                      7α-hydroxycholest-4-en-3-one 12α-hydroxylase. Now included with EC, 5β-cholestane-3α,7α-diol 12α-hydroxylase 
                EC                      5β-cholestane-3α,7α-diol 12α-hydroxylase. Now EC, 5β-cholestane-3α,7α-diol 12α-hydroxylase 
                EC                      taurochenodeoxycholate 6α-hydroxylase. Now EC, taurochenodeoxycholate 6α-hydroxylase 
                EC                      cholesterol 24-hydroxylase. Now EC, cholesterol 24-hydroxylase  
                EC                      24-hydroxycholesterol 7α-hydroxylase. Now EC, 24-hydroxycholesterol 7α-hydroxylase 
                EC                      25/26-hydroxycholesterol 7α-hydroxylase. Now classified as EC, 25/26-hydroxycholesterol 7α-hydroxylase 
                EC                      senecionine N-oxygenase 
                EC                      psoralen synthase. Now EC, psoralen synthase 
                EC                      8-dimethylallylnaringenin 2-hydroxylase. Now EC, 8-dimethylallylnaringenin 2-hydroxylase 
                EC                      (+)-menthofuran synthase. Now EC, (+)-menthofuran synthase 
                EC                      monocyclic monoterpene ketone monooxygenase 
                EC                      epi-isozizaene 5-monooxygenase, now classified as EC, epi-isozizaene 5-monooxygenase. 
                EC                      limonene 1,2-monooxygenase 
                EC                      abieta-7,13-diene hydroxylase. Now EC, abieta-7,13-diene hydroxylase 
                EC                      abieta-7,13-dien-18-ol hydroxylase. Now EC, abieta-7,13-dien-18-ol hydroxylase 
                EC                      geranylgeraniol 18-hydroxylase. Now EC, geranylgeraniol 18-hydroxylase 
                EC                      methanesulfonate monooxygenase (NADH) 
                EC                      3-epi-6-deoxocathasterone 23-monooxygenase. Now EC, 3-epi-6-deoxocathasterone 23-monooxygenase 
                EC                      FAD-dependent urate hydroxylase 
                EC                      6-hydroxynicotinate 3-monooxygenase 
                EC                      angelicin synthase. Now EC, angelicin synthase 
                EC                      geranylhydroquinone 3-hydroxylase. Now EC, geranylhydroquinone 3-hydroxylase. 
                EC                      isoleucine N-monooxygenase, Now EC, isoleucine N-monooxygenase 
                EC                      valine N-monooxygenase. Now EC, valine N-monooxygenase 
                EC                      5-epiaristolochene 1,3-dihydroxylase. Now EC, 5-epiaristolochene 1,3-dihydroxylase 
                EC                      costunolide synthase. Now EC, costunolide synthase 
                EC                      premnaspirodiene oxygenase. Now EC, premnaspirodiene oxygenase 
                EC                      chlorophyllide-a oxygenase 
                EC                      germacrene A hydroxylase. Now EC, germacrene A hydroxylase 
                EC                      phenylalanine N-monooxygenase, now classified as EC, phenylalanine N-monooxygenase 
                EC                      tryptophan N-monooxygenase. Now EC, tryptophan N-monooxygenase 
                EC                      vitamin D3 24-hydroxylase. Now EC, vitamin D3 24-hydroxylase 
                EC                      3-(3-hydroxyphenyl)propanoate hydroxylase 
                EC                      7-methylxanthine demethylase 
                EC                      β-carotene 3-hydroxylase. Now EC, β-carotene 3-hydroxylase. 
                EC                      pyrrole-2-carboxylate monooxygenase 
                EC                      dissimilatory dimethyl sulfide monooxygenase 
                EC                      squalene monooxygenase. Now EC, squalene monooxygenase 
                EC                      pentalenene oxygenase. Now EC, pentalenene oxygenase 
                EC                      β-amyrin 11-oxidase. Now EC, β-amyrin 11-oxidase 
                EC                      1-hydroxy-2-naphthoate hydroxylase 
                EC                      2-hydroxyisoflavanone synthase. Now EC, 2-hydroxyisoflavanone synthase 
                EC                      indole-2-monooxygenase. Now EC, indole-2-monooxygenase 
                EC                      indolin-2-one monooxygenase. Now EC, indolin-2-one monooxygenase 
                EC                      3-hydroxyindolin-2-one monooxygenase. Now EC, 3-hydroxyindolin-2-one monooxygenase 
                EC                      2-hydroxy-1,4-benzoxazin-3-one monooxygenase. Now EC, 2-hydroxy-1,4-benzoxazin-3-one monooxygenase. 
                EC                      cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]. Now EC, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming].. 
                EC                      3-ketosteroid 9α-monooxygenase. Now EC, 3-ketosteroid 9α-monooxygenase 
                EC                      ent-isokaurene C2-hydroxylase. Now EC ent-isokaurene C2/C3-hydroxylase 
                EC                      9β-pimara-7,15-diene oxidase. Now EC, 9β-pimara-7,15-diene oxidase. 
                EC                      ent-cassa-12,15-diene 11-hydroxylase. Now EC, ent-cassa-12,15-diene 11-hydroxylase. 
                EC                      taxoid 14β-hydroxylase 
                EC                      taxoid 7β-hydroxylase. Now EC, taxoid 7β-hydroxylase 
                EC                      trimethylamine monooxygenase 
                EC                      phenylacetyl-CoA 1,2-epoxidase 
                EC                      α-humulene 10-hydroxylase. Now EC, α-humulene 10-hydroxylase. 
                EC                      linalool 8-monooxygenase. Now EC, linalool 8-monooxygenase 
                EC                      geraniol 8-hydroxylase. Now EC, geraniol 8-hydroxylase 
                EC                      (+)-sabinene 3-hydroxylase 
                EC                      erythromycin 12-hydroxylase 
                EC                      α-pinene monooxygenase 
                EC                      1,8-cineole 2-endo-monooxygenase. Now EC, 1,8-cineole 2-endo-monooxygenase 
                EC                      1,8-cineole 2-exo-monooxygenase. Now EC, 1,8-cineole 2-exo-monooxygenase 
                EC                      amorpha-4,11-diene 12-monooxygenase. Now EC, amorpha-4,11-diene 12-monooxygenase. 
                EC                      vitamin D 25-hydroxylase. Now EC, vitamin D 25-hydroxylase 
                EC                      (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase 
                EC                      (+)-camphor 6-exo-hydroxylase 
                EC                      2,5-diketocamphane 1,2-monooxygenase. Now EC, 2,5-diketocamphane 1,2-monooxygenase 
                EC                      6-hydroxy-3-succinoylpyridine 3-monooxygenase 
                EC                      carotenoid isomerooxygenase. The enzyme was discovered at the public-review stage to have been misclassified and so was withdrawn. See EC, carotenoid isomerooxygenase 
                EC                      nitric-oxide synthase [NAD(P)H]. Now classified as EC, nitric-oxide synthase (flavodoxin) 
                EC                      4-nitrocatechol 4-monooxygenase 
                EC                      4-nitrophenol 4-monooxygenase 
                EC                      indole-3-pyruvate monooxygenase 
                EC                      sphinganine C4-monooxygenase. Now EC, sphingolipid C4-monooxygenase 
                EC                      pentalenolactone D synthase 
                EC                      neopentalenolactone D synthase 
                EC                      salicylate 5-hydroxylase 
                EC                      11-oxo-β-amyrin 30-oxidase. Now EC, 11-oxo-β-amyrin 30-oxidase. 
                EC                      averantin hydroxylase. Now EC, averantin hydroxylase 
                EC                      aflatoxin B synthase. Now EC, aflatoxin B synthase 
                EC                      tryprostatin B 6-hydroxylase. Now EC, tryprostatin B 6-hydroxylase 
                EC                      fumitremorgin C monooxygenase. Now EC, fumitremorgin C monooxygenase 
                EC                      methylxanthine N1-demethylase 
                EC                      methylxanthine N3-demethylase 
                EC                      aklavinone 12-hydroxylase 
                EC                      13-deoxydaunorubicin hydroxylase 
                EC                      2-heptyl-3-hydroxy-4(1H)-quinolone synthase 
                EC                      dammarenediol 12-hydroxylase. Now EC, dammarenediol 12-hydroxylase 
                EC                      protopanaxadiol 6-hydroxylase. Now EC, protopanaxadiol 6-hydroxylase 
                EC                      pikromycin synthase. Now EC, pikromycin synthase 
                EC                      20-oxo-5-O-mycaminosyltylactone 23-monooxygenase. Now EC, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase 
                EC                      L-evernosamine nitrososynthase 
                EC                      6-deoxyerythronolide B hydroxylase. Now EC, 6-deoxyerythronolide B hydroxylase 
                EC                      5-methyl-1-naphthoate 3-hydroxylase 
                EC                      ferruginol synthase. Now EC, ferruginol synthase 
                EC                      ent-sandaracopimaradiene 3-hydroxylase. Now EC, ent-sandaracopimaradiene 3-hydroxylase 
                EC                      oryzalexin E synthase. Now EC, oryzalexin E synthase 
                EC                      oryzalexin D synthase. Now EC, oryzalexin D synthase 
                EC                      phylloquinone ω-hydroxylase. Now EC, phylloquinone ω-hydroxylase 
                EC                      L-ornithine N5-monooxygenase (NADPH) 
                EC                      L-ornithine N5-monooxygenase [NAD(P)H] 
                EC                      dihydromonacolin L hydroxylase. Now EC, dihydromonacolin L hydroxylase 
                EC                      monacolin L hydroxylase. Now EC, monacolin L hydroxylase 
                EC                      docosahexaenoic acid ω-hydroxylase. Now EC, docosahexaenoic acid ω-hydroxylase 
                EC                      tetracenomycin A2 monooxygenase-dioxygenase 
                EC                      β-amyrin 28-monooxygenase. Now EC, β-amyrin 28-monooxygenase 
                EC                      methyl farnesoate epoxidase. Now EC, methyl farnesoate epoxidase 
                EC                      farnesoate epoxidase. Now EC, farnesoate epoxidase 
                EC                      long-chain acyl-CoA ω-monooxygenase. Now EC, long-chain acyl-CoA ω-monooxygenase 
                EC                      long-chain fatty acid ω-monooxygenase. Now EC, long-chain fatty acid ω-monooxygenase 
                EC                      laurate 7-monooxygenase. Now EC, laurate 7-monooxygenase 
                EC                      ipsdienol synthase. Now EC, ipsdienol synthase 
                EC                      benzoyl-CoA 2,3-epoxidase 
                EC                      salicyloyl-CoA 5-hydroxylase 
                EC                      4-methyl-5-nitrocatechol 5-monooxygenase 
                EC                      rifampicin monooxygenase 
                EC                      1,3,7-trimethyluric acid 5-monooxygenase 
                EC                      bursehernin 5-monooxygenase. Now EC, bursehernin 5-monooxygenase 
                EC                      (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase. Now EC, (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase 
                EC                      protoasukamycin 4-monooxygenase 
                EC                      asperlicin C monooxygenase 
                EC                      protodeoxyviolaceinate monooxygenase 
                EC                      5-methylphenazine-1-carboxylate 1-monooxygenase 
                EC                      resorcinol 4-hydroxylase (NADPH) 
                EC                      resorcinol 4-hydroxylase (NADH) 
                EC                      cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]. Now EC, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] 
                EC                      aurachin C monooxygenase/isomerase 
                EC                      3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase 
                EC                      violacein synthase 
                EC                      F-actin monooxygenase 
                EC                      acetone monooxygenase (methyl acetate-forming) 
                EC                      propane 2-monooxygenase 
                EC                      jasmonic acid 12-hydroxylase 
                EC                      tert-butyl alcohol monooxygenase 
                EC                      butane monooxygenase (soluble) 
                EC                      tetracycline 11a-monooxygenase 
                EC                      6-methylpretetramide 4-monooxygenase 
                EC                      4-hydroxy-6-methylpretetramide 12a-monooxygenase 
                EC                      5a,11a-dehydrotetracycline 5-monooxygenase 
                EC                      indole-3-acetate monooxygenase 
                EC                      toluene 4-monooxygenase 
                EC                      aliphatic glucosinolate S-oxygenase 
                EC                      dimethylamine monooxygenase 
                EC                      carnitine monooxygenase 
                EC                      2-polyprenylphenol 6-hydroxylase 
                EC                      5-pyridoxate monooxygenase 
                EC                      3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase 
                EC                      toluene 2-monooxygenase 
                EC                      phenol 2-monooxygenase (NADH) 
                EC                      assimilatory dimethylsulfide S-monooxygenase 
                EC                      4β-methylsterol monooxygenase 
                EC                      stachydrine N-demethylase 
                EC                      L-aspartate N-monooxygenase (nitrosuccinate-forming) 
                EC                      3-amino-4-hydroxybenzoate 2-monooxygenase 
                EC                      nitrosourea synthase 
                EC                      glycine betaine monooxygenase 
        EC 1.14.14       [+]    With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor 
        EC 1.14.15       [+]    With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor 
        EC 1.14.16       [+]    With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor 
        EC 1.14.17       [+]    With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor 
        EC 1.14.18       [+]    With another compound as one donor, and incorporation of one atom of oxygen into the other donor 
        EC 1.14.19       [+]    With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water 
        EC 1.14.20       [+]    With 2-oxoglutarate as one donor, and the other dehydrogenated 
        EC 1.14.21       [+]    With NADH or NADPH as one donor, and the other dehydrogenated 
        EC 1.14.99       [+]    Miscellaneous 
    EC 1.15  [+]      
    EC 1.16  [+]      
    EC 1.17  [+]      
    EC 1.18  [+]      
    EC 1.19  [+]      
    EC 1.20  [+]      
    EC 1.21  [+]      
    EC 1.22  [+]      
    EC 1.23  [+]      
    EC 1.97  [+]      
    EC 1.98  [+]      
    EC 1.99  [+]      
EC 2 [+]   
EC 3 [+]   
EC 4 [+]   
EC 5 [+]   
EC 6 [+]   
EC 7 [+]   

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