EC 1 [+ ]
Oxidoreductases EC 2 [+ ]
Transferases EC 3 [– ]
Hydrolases EC 3.1 [+ ]
Acting on ester bonds EC 3.2 [+ ]
Glycosylases EC 3.3 [+ ]
Acting on ether bonds EC 3.4 [– ]
Acting on peptide bonds (peptidases) EC 3.4.1 [+ ] α-Amino-acyl-peptide hydrolases (deleted sub-subclass) EC 3.4.2 [+ ] Peptidyl-amino-acid hydrolases (deleted sub-subclass) EC 3.4.3 [+ ] Dipeptide hydrolases (deleted sub-subclass) EC 3.4.4 [+ ] Peptidyl peptide hydrolases (deleted sub-subclass) EC 3.4.11 [+ ] Aminopeptidases EC 3.4.12 [+ ] Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass) EC 3.4.13 [+ ] Dipeptidases EC 3.4.14 [+ ] Dipeptidyl-peptidases and tripeptidyl-peptidases EC 3.4.15 [+ ] Peptidyl-dipeptidases EC 3.4.16 [+ ] Serine-type carboxypeptidases EC 3.4.17 [+ ] Metallocarboxypeptidases EC 3.4.18 [+ ] Cysteine-type carboxypeptidases EC 3.4.19 [+ ] Omega peptidases EC 3.4.21 [– ] Serine endopeptidases EC 3.4.21.1 chymotrypsin EC 3.4.21.2 chymotrypsin C EC 3.4.21.3 metridin EC 3.4.21.4 trypsin EC 3.4.21.5 thrombin EC 3.4.21.6 coagulation factor Xa EC 3.4.21.7 plasmin EC 3.4.21.8 kallikrein. Now EC 3.4.21.34 (plasma kallikrein) and EC 3.4.21.35 (tissue kallikrein) EC 3.4.21.9 enteropeptidase EC 3.4.21.10 acrosin EC 3.4.21.11 elastase. Now EC 3.4.21.37 , leukocyte elastase EC 3.4.21.12 α-lytic endopeptidase EC 3.4.21.13 Phaseolus proteinase. Now EC 3.4.16.6 , carboxypeptidase D EC 3.4.21.14 now EC 3.4.21.67 endopeptidase So EC 3.4.21.15 Aspergillus alkaline proteinase. Now EC 3.4.21.63 , oryzin EC 3.4.21.16 Alternaria serine proteinase EC 3.4.21.17 Arthrobacter serine proteinase EC 3.4.21.18 Tenebrio α-proteinase EC 3.4.21.19 glutamyl endopeptidase EC 3.4.21.20 cathepsin G EC 3.4.21.21 coagulation factor VIIa EC 3.4.21.22 coagulation factor IXa EC 3.4.21.23 Vipera russelli proteinase EC 3.4.21.24 red cell neutral endopeptidase EC 3.4.21.25 cucumisin EC 3.4.21.26 prolyl oligopeptidase EC 3.4.21.27 coagulation factor XIa EC 3.4.21.28 Agkistrodon serine proteinase. Now EC 3.4.21.74 , venombin A EC 3.4.21.29 Bothrops atrox serine proteinase. Now EC 3.4.21.74 , venombin A EC 3.4.21.30 Crotalus adamanteus serine proteinase. Now EC 3.4.21.74 , venombin A EC 3.4.21.31 urokinase. Now EC 3.4.21.73 , u-plasminogen activator EC 3.4.21.32 brachyurin EC 3.4.21.33 Entomophthora collagenolytic proteinase EC 3.4.21.34 plasma kallikrein EC 3.4.21.35 tissue kallikrein EC 3.4.21.36 pancreatic elastase EC 3.4.21.37 leukocyte elastase EC 3.4.21.38 coagulation factor XIIa EC 3.4.21.39 chymase EC 3.4.21.40 submandibular proteinase A EC 3.4.21.41 complement subcomponent C1r EC 3.4.21.42 complement subcomponent C1s EC 3.4.21.43 classical-complement-pathway C3/C5 convertase EC 3.4.21.44 complement component C5 convertase. Now EC 3.4.21.43 , classical-complement-pathway C3/C5 convertase EC 3.4.21.45 complement factor I EC 3.4.21.46 complement factor D EC 3.4.21.47 alternative-complement-pathway C3/C5 convertase EC 3.4.21.48 cerevisin EC 3.4.21.49 hypodermin C EC 3.4.21.50 lysyl endopeptidase EC 3.4.21.51 Leukocyte-membrane neutral endopeptidase EC 3.4.21.52 Cathepsin R EC 3.4.21.53 endopeptidase La EC 3.4.21.54 γ-renin EC 3.4.21.55 venombin AB EC 3.4.21.56 euphorbain. Now considered EC 3.4.21.25 , cucumisin EC 3.4.21.57 leucyl endopeptidase EC 3.4.21.58 prohormone serine proteinase EC 3.4.21.59 tryptase EC 3.4.21.60 scutelarin EC 3.4.21.61 kexin EC 3.4.21.62 subtilisin EC 3.4.21.63 oryzin EC 3.4.21.64 peptidase K EC 3.4.21.65 thermomycolin EC 3.4.21.66 thermitase EC 3.4.21.67 endopeptidase So EC 3.4.21.68 t -plasminogen activator EC 3.4.21.69 protein C (activated) EC 3.4.21.70 pancreatic endopeptidase E EC 3.4.21.71 pancreatic elastase II EC 3.4.21.72 IgA-specific serine endopeptidase EC 3.4.21.73 u-plasminogen activator EC 3.4.21.74 venombin A EC 3.4.21.75 furin EC 3.4.21.76 myeloblastin EC 3.4.21.77 semenogelase EC 3.4.21.78 granzyme A EC 3.4.21.79 granzyme B EC 3.4.21.80 streptogrisin A EC 3.4.21.81 streptogrisin B EC 3.4.21.82 glutamyl endopeptidase II EC 3.4.21.83 oligopeptidase B EC 3.4.21.84 limulus clotting factor C EC 3.4.21.85 limulus clotting factor B EC 3.4.21.86 limulus clotting enzyme EC 3.4.21.87 omptin. Now EC 3.4.23.49 , omptin. The enzyme is not a serine protease, as thought previously, but an aspartate protease EC 3.4.21.88 repressor LexA EC 3.4.21.89 signal peptidase I EC 3.4.21.90 togavirin EC 3.4.21.91 flavivirin EC 3.4.21.92 endopeptidase Clp EC 3.4.21.93 proprotein convertase 1 EC 3.4.21.94 proprotein convertase 2 EC 3.4.21.95 snake venom factor V activator EC 3.4.21.96 lactocepin EC 3.4.21.97 assemblin EC 3.4.21.98 hepacivirin EC 3.4.21.99 spermosin EC 3.4.21.100 sedolisin EC 3.4.21.101 xanthomonalisin EC 3.4.21.102 C-terminal processing peptidase EC 3.4.21.103 physarolisin EC 3.4.21.104 mannan-binding lectin-associated serine protease-2 EC 3.4.21.105 rhomboid protease EC 3.4.21.106 hepsin EC 3.4.21.107 peptidase Do EC 3.4.21.108 HtrA2 peptidase EC 3.4.21.109 matriptase EC 3.4.21.110 C5a peptidase EC 3.4.21.111 aqualysin 1 EC 3.4.21.112 site-1 protease EC 3.4.21.113 pestivirus NS3 polyprotein peptidase EC 3.4.21.114 equine arterivirus serine peptidase EC 3.4.21.115 infectious pancreatic necrosis birnavirus Vp4 peptidase EC 3.4.21.116 SpoIVB peptidase EC 3.4.21.117 stratum corneum chymotryptic enzyme EC 3.4.21.118 kallikrein 8 EC 3.4.21.119 kallikrein 13 EC 3.4.21.120 oviductin EC 3.4.21.121 Lys-Lys/Arg-Xaa endopeptidase EC 3.4.21.122 transmembrane protease serine 2 EC 3.4.22 [+ ] Cysteine endopeptidases EC 3.4.23 [+ ] Aspartic endopeptidases EC 3.4.24 [+ ] Metalloendopeptidases EC 3.4.25 [+ ] Threonine endopeptidases EC 3.4.99 [+ ] Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty) EC 3.5 [+ ]
Acting on carbon-nitrogen bonds, other than peptide bonds EC 3.6 [+ ]
Acting on acid anhydrides EC 3.7 [+ ]
Acting on carbon-carbon bonds EC 3.8 [+ ]
Acting on halide bonds EC 3.9 [+ ]
Acting on phosphorus-nitrogen bonds EC 3.10 [+ ]
Acting on sulfur-nitrogen bonds EC 3.11 [+ ]
Acting on carbon-phosphorus bonds EC 3.12 [+ ]
Acting on sulfur-sulfur bonds EC 3.13 [+ ]
Acting on carbon-sulfur bonds EC 4 [+ ]
Lyases EC 5 [+ ]
Isomerases EC 6 [+ ]
Ligases EC 7 [+ ]
Translocases
