Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Proposed Changes to the Enzyme List

The entries below are proposed additions and amendments to the Enzyme Nomenclature list. They were prepared for the NC-IUBMB by Kristian Axelsen, Ron Caspi, Ture Damhus, Shinya Fushinobu, Julia Hauenstein, Antje Jäde, Ingrid Keseler, Masaaki Kotera, Andrew McDonald, Gerry Moss, Ida Schomburg and Keith Tipton. Comments and suggestions on these draft entries should be sent to Dr Andrew McDonald (Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland). The date on which an enzyme will be made official is appended after the EC number. To prevent confusion please do not quote new EC numbers until they are incorporated into the main list.

An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.

*EC 1.1.1.48 D-galactose 1-dehydrogenase
*EC 1.1.1.105 all-trans-retinol dehydrogenase (NAD⁺)
*EC 1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5′-phosphate reductase
EC 1.1.1.315 11-cis-retinol dehydrogenase
EC 1.1.1.316 L-galactose 1-dehydrogenase
EC 1.1.1.317 perakine reductase
EC 1.1.3.42 prosolanapyrone-II oxidase
EC 1.1 Acting on the CH-OH group of donors
EC 1.1.9 With a copper protein as acceptor
EC 1.1.9.1 alcohol dehydrogenase (azurin)
EC 1.1.98.1 transferred
EC 1.2.1.82 β-apo-4′-carotenal dehydrogenase
EC 1.3.1.88 tRNA-dihydrouridine^16/17 synthase [NAD(P)⁺]
EC 1.3.1.89 tRNA-dihydrouridine⁴⁷ synthase [NAD(P)⁺]
EC 1.3.1.90 tRNA-dihydrouridine^20a/20b synthase [NAD(P)⁺]
EC 1.3.1.91 tRNA-dihydrouridine²⁰ synthase [NAD(P)⁺]
EC 1.3.8.2 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)
*EC 1.3.8.2 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)
EC 1.4 Acting on the CH-NH₂ group of donors
EC 1.4.9 With a copper protein as acceptor
EC 1.4.9.1 methylamine dehydrogenase (amicyanin)
EC 1.4.9.2 aralkylamine dehydrogenase (azurin)
EC 1.4.98.1 transferred
EC 1.4.99.4 transferred
EC 1.5.1.29 deleted
EC 1.5.1.37 FAD reductase (NADH)
EC 1.5.1.38 FMN reductase (NADPH)
EC 1.5.1.39 FMN reductase [NAD(P)H]
EC 1.5.1.40 8-hydroxy-5-deazaflavin:NADPH oxidoreductase
EC 1.5.1.41 riboflavin reductase [NAD(P)H]
EC 1.5.1.42 FMN reductase (NADH)
EC 1.6.5.10 NADPH dehydrogenase (quinone)
EC 1.6.99.6 transferred
EC 1.7 Acting on other nitrogenous compounds as donors
EC 1.7.6 With a nitrogenous group as acceptor
EC 1.7.6.1 nitrite dismutase
EC 1.10 Acting on diphenols and related substances as donors
EC 1.10.9 With a copper protein as acceptor
EC 1.10.9.1 plastoquinol—plastocyanin reductase
EC 1.10.99.1 transferred
*EC 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
*EC 1.13.11.26 peptide-tryptophan 2,3-dioxygenase
EC 1.13.11.44 deleted
EC 1.13.11.59 torulene dioxygenase
EC 1.13.11.60 linoleate 8R-lipoxygenase
EC 1.13.11.61 linolenate 9R-lipoxygenase
EC 1.13.11.62 linoleate 10R-lipoxygenase
EC 1.13.12.19 2-oxoglutarate dioxygenase (ethene-forming)
EC 1.14.11.34 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
*EC 1.14.12.19 3-phenylpropanoate dioxygenase
EC 1.14.13.3 transferred
EC 1.14.13.131 dissimilatory dimethyl sulfide monooxygenase
EC 1.14.13.132 squalene monooxygenase
EC 1.14.13.133 pentalenene oxygenase
EC 1.14.13.134 β-amyrin 11-oxidase
EC 1.14.13.135 1-hydroxy-2-naphthoate hydroxylase
EC 1.14.13.136 2-hydroxyisoflavanone synthase
EC 1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
EC 1.14.14.10 nitrilotriacetate monooxygenase
EC 1.14.14.11 styrene monooxygenase
EC 1.14.14.12 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
EC 1.14.99.7 transferred
EC 1.16 Oxidizing metal ions
EC 1.16.9 With a copper protein as acceptor
EC 1.16.9.1 iron:rusticyanin reductase
*EC 1.17.1.4 xanthine dehydrogenase
EC 1.17.1.7 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
*EC 1.17.3.2 xanthine oxidase
EC 1.17.7.2 7-hydroxymethyl chlorophyll a reductase
EC 1.20 Acting on phosphorus or arsenic in donors
EC 1.20.2 With a cytochrome as acceptor
EC 1.20.2.1 arsenate reductase (cytochrome c)
EC 1.20 Acting on phosphorus or arsenic in donors
EC 1.20.9 With a copper protein as acceptor
EC 1.20.9.1 arsenate reductase (azurin)
EC 1.20.98.1 transferred
EC 2.1.1.31 transferred
EC 2.1.1.32 transferred
*EC 2.1.1.33 tRNA (guanine⁴⁶-N⁷)-methyltransferase
*EC 2.1.1.35 tRNA (uracil⁵⁴-C⁵)-methyltransferase
EC 2.1.1.36 transferred
*EC 2.1.1.42 flavone 3′-O-methyltransferase
*EC 2.1.1.46 isoflavone 4′-O-methyltransferase
*EC 2.1.1.74 methylenetetrahydrofolate—tRNA-(uracil⁵⁴-C⁵)-methyltransferase [NAD(P)H-oxidizing]
*EC 2.1.1.192 23S rRNA (adenine²⁵⁰³-C²)-methyltransferase
EC 2.1.1.194 deleted
EC 2.1.1.211 tRNA^Ser (uridine⁴⁴-2′-O)-methyltransferase
EC 2.1.1.212 2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase
EC 2.1.1.213 tRNA (guanine¹⁰-N²)-dimethyltransferase
EC 2.1.1.214 tRNA (guanine¹⁰-N²)-methyltransferase
EC 2.1.1.215 tRNA (guanine²⁶-N²/guanine²⁷-N²)-dimethyltransferase
EC 2.1.1.216 tRNA (guanine²⁶-N²)-dimethyltransferase
EC 2.1.1.217 tRNA (adenine²²-N¹)-methyltransferase
EC 2.1.1.218 tRNA (adenine⁹-N¹)-methyltransferase
EC 2.1.1.219 tRNA (adenine⁵⁷-N¹/adenine⁵⁸-N¹)-methyltransferase
EC 2.1.1.220 tRNA (adenine⁵⁸-N¹)-methyltransferase
EC 2.1.1.221 tRNA (guanine⁹-N¹)-methyltransferase
EC 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase
EC 2.1.1.223 tRNA₁^Val (adenine³⁷-N⁶)-methyltransferase
EC 2.1.1.224 23S rRNA (adenine²⁵⁰³-C⁸)-methyltransferase
EC 2.1.1.225 tRNA:m⁴X modification enzyme
EC 2.1.1.226 23S rRNA (cytidine¹⁹²⁰-2′-O)-methyltransferase
EC 2.1.1.227 16S rRNA (cytidine¹⁴⁰⁹-2′-O)-methyltransferase
EC 2.1.1.228 tRNA (guanine³⁷-N¹)-methyltransferase
EC 2.1.1.229 tRNA (carboxymethyluridine³⁴-5-O)-methyltransferase
EC 2.1.1.230 23S rRNA (adenosine¹⁰⁶⁷-2′-O)-methyltransferase
EC 2.1.1.231 flavonoid 4′-O-methyltransferase
EC 2.1.1.232 naringenin 7-O-methyltransferase
EC 2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase
EC 2.1.1.234 dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose N,N-dimethyltransferase
EC 2.1.1.235 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose N,N-dimethyltransferase
EC 2.1.1.236 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose N,N-dimethyltransferase
EC 2.1.1.237 mycinamicin III 3′′-O-methyltransferase
EC 2.1.1.238 mycinamicin VI 2′′-O-methyltransferase
*EC 2.3.1.135 phosphatidylcholine—retinol O-acyltransferase
*EC 2.3.2.2 γ-glutamyltransferase
*EC 2.4.1.180 lipopolysaccharide N-acetylmannosaminouronosyltransferase
EC 2.4.1.271 crocetin glucosyltransferase
EC 2.4.1.272 soyasapogenol B glucuronide galactosyltransferase
EC 2.4.1.273 soyasaponin III rhamnosyltransferase
EC 2.4.1.274 glucosylceramide β-1,4-galactosyltransferase
EC 2.4.1.275 neolactotriaosylceramide β-1,4-galactosyltransferase
EC 2.4.1.276 zeaxanthin glucosyltransferase
EC 2.4.1.277 10-deoxymethynolide desosaminyltransferase
*EC 2.4.99.12 lipid IV_A 3-deoxy-D-manno-octulosonic acid transferase
*EC 2.4.99.13 (Kdo)-lipid IV_A 3-deoxy-D-manno-octulosonic acid transferase
*EC 2.4.99.14 (Kdo)₂-lipid IV_A (2-8) 3-deoxy-D-manno-octulosonic acid transferase
*EC 2.4.99.15 (Kdo)₃-lipid IV_A (2-4) 3-deoxy-D-manno-octulosonic acid transferase
EC 2.5.1.95 xanthan ketal pyruvate transferase
EC 2.5.1.96 4,4′-diapophytoene synthase
EC 2.5.1.97 pseudaminic acid synthase
EC 2.6.1.88 methionine transaminase
EC 2.6.1.89 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose transaminase
EC 2.6.1.90 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose transaminase
EC 2.6.1.91 UDP-4-amino-4,6-dideoxy-N-acetyl-α-D-glucosamine transaminase
EC 2.6.1.92 UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine transaminase
*EC 2.7.1.61 acyl-phosphate—hexose phosphotransferase
*EC 2.7.1.119 hygromycin-B 7′′-O-kinase
*EC 2.7.1.166 3-deoxy-D-manno-octulosonic acid kinase
*EC 2.7.1.170 anhydro-N-acetylmuramic acid kinase
EC 2.7.7.77 molybdenum cofactor guanylyltransferase
EC 2.7.7.78 GDP-D-glucose phosphorylase
EC 2.7.7.79 tRNA^His guanylyltransferase
EC 2.7.7.80 molybdopterin-synthase adenylyltransferase
*EC 2.8.1.7 cysteine desulfurase
EC 2.8.1.9 molybdenum cofactor sulfurtransferase
EC 2.8.1.10 thiazole synthase
EC 2.8.1.11 molybdopterin synthase sulfurtransferase
EC 2.8.1.12 molybdopterin synthase
*EC 2.8.4.1 coenzyme-B sulfoethylthiotransferase
EC 3.1.1.21 deleted
*EC 3.1.1.64 retinoid isomerohydrolase
EC 3.1.1.89 protein phosphatase methylesterase-1
EC 3.1.1.90 all-trans-retinyl ester 13-cis isomerohydrolase
EC 3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
EC 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
EC 3.1.7.8 tuberculosinol synthase
EC 3.1.7.9 isotuberculosinol synthase
*EC 3.2.1.32 endo-1,3-β-xylanase
*EC 3.2.1.47 galactosylgalactosylglucosylceramidase
*EC 3.2.1.91 cellulose 1,4-β-cellobiosidase (non-reducing end)
*EC 3.2.1.99 arabinan endo-1,5-α-L-arabinanase
*EC 3.2.1.155 xyloglucan-specific endo-processive β-1,4-glucanase
EC 3.2.1.176 cellulose 1,4-β-cellobiosidase (reducing end)
EC 3.2.1.177 α-D-xyloside xylohydrolase
EC 3.2.1.178 β-porphyranase
EC 3.2.1.179 gellan tetrasaccharide unsaturated glucuronosyl hydrolase
EC 3.2.1.180 unsaturated chondroitin disaccharide hydrolase
EC 3.4.11.26 intermediate cleaving peptidase 55
EC 3.4.19.13 glutathione γ-glutamate hydrolase
*EC 3.4.22.68 Ulp1 peptidase
EC 3.4.23.52 preflagellin peptidase
*EC 3.5.1.94 γ-glutamyl-γ-aminobutyrate hydrolase
EC 3.5.1.109 sphingomyelin deacylase
*EC 3.5.99.2 aminopyrimidine aminohydrolase
EC 3.6.1.55 8-oxo-dGTP diphosphatase
EC 3.6.1.56 2-hydroxy-dATP diphosphatase
EC 3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase
*EC 3.6.3.8 Ca²⁺-transporting ATPase
EC 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
EC 3.7.1.15 (+)-caryolan-1-ol synthase
EC 3.7.1.16 oxepin-CoA hydrolase
*EC 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
EC 4.1.1.93 pyrrole-2-carboxylate decarboxylase
*EC 4.1.2.5 L-threonine aldolase
EC 4.1.2.48 low-specificity L-threonine aldolase
EC 4.1.2.49 L-allo-threonine aldolase
EC 4.1.99.17 phosphomethylpyrimidine synthase
EC 4.1.99.18 cyclic pyranopterin phosphate synthase
EC 4.1.99.19 2-iminoacetate synthase
*EC 4.2.1.20 tryptophan synthase
*EC 4.2.1.83 4-oxalomesaconate hydratase
EC 4.2.1.130 D-lactate dehydratase
EC 4.2.1.131 carotenoid 1,2-hydratase
EC 4.2.2.25 gellan lyase
*EC 4.2.3.57 (-)-β-caryophyllene synthase
*EC 4.2.3.62 (-)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]
EC 4.2.3.78 β-chamigrene synthase
EC 4.2.3.79 thujopsene synthase
EC 4.2.3.80 α-longipinene synthase
EC 4.2.3.81 exo-α-bergamotene synthase
EC 4.2.3.82 α-santalene synthase
EC 4.2.3.83 β-santalene synthase
EC 4.2.3.84 10-epi-γ-eudesmol synthase
EC 4.2.3.85 α-eudesmol synthase
EC 4.2.3.86 7-epi-α-selinene synthase
EC 4.2.3.87 α-guaiene synthase
EC 4.2.3.88 viridiflorene synthase
EC 4.2.3.89 (+)-β-caryophyllene synthase
EC 4.2.3.90 5-epi-α-selinene synthase
EC 4.2.3.91 cubebol synthase
EC 4.2.3.92 (+)-γ-cadinene synthase
EC 4.2.3.93 δ-guaiene synthase
EC 4.3.3.6 pyridoxal 5′-phosphate synthase (glutamine hydrolysing)
EC 5.1.3.24 N-acetylneuraminate epimerase
EC 5.2.1.3 deleted
EC 5.2.1.7 transferred
EC 5.3.2.3 TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-α-D-galactopyranose-forming)
EC 5.3.2.4 TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-α-D-glucopyranose-forming)
*EC 5.3.3.16 4-oxalomesaconate tautomerase
EC 5.3.3.18 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase
EC 5.4.4.5 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
EC 5.4.4.6 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
*EC 5.4.99.25 tRNA pseudouridine⁵⁵ synthase
EC 5.4.99.42 tRNA pseudouridine³¹ synthase
EC 5.4.99.43 21S rRNA pseudouridine²⁸¹⁹ synthase
EC 5.4.99.44 mitochondrial tRNA pseudouridine^27/28 synthase
EC 5.4.99.45 tRNA pseudouridine^38/39 synthase
EC 5.4.99.46 shionone synthase
EC 5.4.99.47 parkeol synthase
EC 5.4.99.48 achilleol B synthase
EC 5.4.99.49 glutinol synthase
EC 5.4.99.50 friedelin synthase
EC 5.4.99.51 baccharis oxide synthase
EC 5.4.99.52 α-seco-amyrin synthase
EC 5.4.99.53 marneral synthase
EC 5.4.99.54 β-seco-amyrin synthase
EC 5.4.99.55 δ-amyrin synthase
EC 5.4.99.56 tirucalladienol synthase
EC 5.5.1.18 lycopene ε-cyclase
EC 5.5.1.19 lycopene β-cyclase
EC 5.5.1.20 prosolanapyrone-III cycloisomerase
*EC 6.2.1.2 medium-chain acyl-CoA ligase
*EC 6.2.1.3 long-chain-fatty-acid—CoA ligase
*EC 6.2.1.10 carboxylic acid—CoA ligase (GDP-forming)
*EC 6.2.1.19 long-chain-fatty-acid—protein ligase
*EC 6.2.1.23 dicarboxylate—CoA ligase

Proposed Changes to the Enzyme List

Contents