EC |
1.1.1.104 |
Accepted name: |
4-oxoproline reductase |
Reaction: |
cis-4-hydroxy-L-proline + NAD+ = 4-oxo-L-proline + NADH + H+ |
Other name(s): |
cis-hydroxy-L-proline oxidase |
Systematic name: |
cis-4-hydroxy-L-proline:NAD+ oxidoreductase (4-oxo-L-proline forming) |
Comments: |
The enzyme, isolated from animals, is specific for 4-oxo-L-proline and cis-4-hydroxy-L-proline. It has no activity with trans-4-hydroxy-L-proline. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37250-37-6 |
References: |
1. |
Smith, T.E. and Mitoma, C. Partial purification and some properties of 4-ketoproline reductase. J. Biol. Chem. 237 (1962) 1177–1180. [PMID: 13914427] |
2. |
Kwiatkowski, S., Bozko, M., Zarod, M., Witecka, A., Kocdemir, K., Jagielski, A.K. and Drozak, J. Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase (BDH2) as 4-oxo-L-proline reductase (EC 1.1.1.104). J. Biol. Chem. 298:101708 (2022). [DOI] [PMID: 35150746] |
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[EC 1.1.1.104 created 1972, modified 2022] |
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