| EC |
1.1.1.149 |
| Accepted name: |
20α-hydroxysteroid dehydrogenase |
| Reaction: |
17α,20α-dihydroxypregn-4-en-3-one + NAD(P)+ = 17α-hydroxyprogesterone + NAD(P)H + H+ |
| Other name(s): |
20α-hydroxy steroid dehydrogenase; 20α-HSD; 20α-HSDH |
| Systematic name: |
20α-hydroxysteroid:NAD(P)+ 20-oxidoreductase |
| Comments: |
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17β-estradiol 17-dehydrogenase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9040-08-8 |
| References: |
| 1. |
Shikita, M., Inano, H. and Tamaoki, B. Further studies on 20α-hydroxysteroid dehydrogenase of rat testes. Biochemistry 6 (1967) 1760–1764. [PMID: 4382486] |
| 2. |
Strickler, R.C., Tobias, B. and Covey, D.F. Human placental 17β-estradiol dehydrogenase and 20α-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site. J. Biol. Chem. 256 (1981) 316–321. [PMID: 6935192] |
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| [EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986] |
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