The Enzyme Database

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Accepted name: 20α-hydroxysteroid dehydrogenase
Reaction: 17α,20α-dihydroxypregn-4-en-3-one + NAD(P)+ = 17α-hydroxyprogesterone + NAD(P)H + H+
Other name(s): 20α-hydroxy steroid dehydrogenase; 20α-HSD; 20α-HSDH
Systematic name: 20α-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Comments: Re-specific with respect to NAD(P)+ (cf. EC 17β-estradiol 17-dehydrogenase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9040-08-8
1.  Shikita, M., Inano, H. and Tamaoki, B. Further studies on 20α-hydroxysteroid dehydrogenase of rat testes. Biochemistry 6 (1967) 1760–1764. [PMID: 4382486]
2.  Strickler, R.C., Tobias, B. and Covey, D.F. Human placental 17β-estradiol dehydrogenase and 20α-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site. J. Biol. Chem. 256 (1981) 316–321. [PMID: 6935192]
[EC created 1972, deleted 1983, reinstated 1986]

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