EC |
1.1.1.181 |
Accepted name: |
cholest-5-ene-3β,7α-diol 3β-dehydrogenase |
Reaction: |
cholest-5-ene-3β,7α-diol + NAD+ = 7α-hydroxycholest-4-en-3-one + NADH + H+ |
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For diagram of cholesterol catabolism (rings A, B and C), click here |
Other name(s): |
3β-hydroxy-Δ5-C27-steroid oxidoreductase (ambiguous) |
Systematic name: |
cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase |
Comments: |
Highly specific for 3β,7α-dihydroxy-C27-steroids with Δ5-double bond. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 56626-16-5 |
References: |
1. |
Wikvall, K. Purification and properties of a 3β-hydroxy-Δ5-C27-steroid oxidoreductase from rabbit liver microsomes. J. Biol. Chem. 256 (1981) 3376–3380. [PMID: 6937465] |
2. |
Schwarz, M., Wright, A.C., Davis, D.L., Nazer, H., Bjorkhem, I. and Russell, D.W. The bile acid synthetic gene 3β-hydroxy-Δ5-C27-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. J. Clin. Invest. 106 (2000) 1175–1184. [PMID: 11067870] |
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[EC 1.1.1.181 created 1983] |
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