| EC |
1.1.1.205 |
| Accepted name: |
IMP dehydrogenase |
| Reaction: |
IMP + NAD+ + H2O = XMP + NADH + H+ |
|
For diagram of AMP and GMP biosynthesis, click here |
| Glossary: |
IMP = inosine 5′-phosphate
XMP = xanthosine 5′-phosphate |
| Other name(s): |
inosine-5′-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5′-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase |
| Systematic name: |
IMP:NAD+ oxidoreductase |
| Comments: |
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-93-7 |
| References: |
| 1. |
Magasanik, B., Moyed, H.S. and Gehring, L.B. Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5′-phosphate dehydrogenase of Aerobacter aerogenes. J. Biol. Chem. 226 (1957) 339–350. [PMID: 13428767] |
| 2. |
Turner, J.F. and King, J.E. Inosine 5-phosphate dehydrogenase of pea seeds. Biochem. J. 79 (1961) 147. [PMID: 13778733] |
|
| [EC 1.1.1.205 created 1961 as EC 1.2.1.14, transferred 1984 to EC 1.1.1.205] |
| |
|
| |
|
Printable version