| EC |
1.1.1.209 |
| Accepted name: |
3(or 17)α-hydroxysteroid dehydrogenase |
| Reaction: |
androsterone + NAD(P)+ = 5α-androstane-3,17-dione + NAD(P)H + H+ |
| Other name(s): |
3(17)α-hydroxysteroid dehydrogenase |
| Systematic name: |
3(or 17)α-hydroxysteroid:NAD(P)+ oxidoreductase |
| Comments: |
Acts on the 3α-hydroxy group of androgens of the 5α-androstane series; and also, more slowly, on the 17α-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)β-hydroxysteroid dehydrogenase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 83294-77-3 |
| References: |
| 1. |
Lau, P.C.K., Layne, D.S. and Williamson, D.G. A 3(17)α-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme. J. Biol. Chem. 257 (1982) 9444–9449. [PMID: 6955302] |
| 2. |
Lau, P.C.K., Layne, D.S. and Williamson, D.G. Comparison of the multiple forms of the soluble 3(17)α-hydroxysteroid dehydrogenases of female rabbit kidney and liver. J. Biol. Chem. 257 (1982) 9450–9456. [PMID: 6955303] |
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| [EC 1.1.1.209 created 1986] |
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