| EC |
1.1.1.218 |
| Accepted name: |
morphine 6-dehydrogenase |
| Reaction: |
morphine + NAD(P)+ = morphinone + NAD(P)H + H+ |
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For diagram of morphine biosynthesis, click here |
| Other name(s): |
naloxone reductase |
| Systematic name: |
morphine:NAD(P)+ 6-oxidoreductase |
| Comments: |
Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6α-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 97002-71-6 |
| References: |
| 1. |
Yamano, S., Kaguera, E., Ishida, T. and Toki, S. Purification and characterization of guinea pig liver morphine 6-dehydrogenase. J. Biol. Chem. 260 (1985) 5259–5264. [PMID: 2580834] |
| 2. |
Yamano, S., Nishida, F. and Toki, S. Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase. Biochem. Pharmacol. 35 (1986) 4321–4326. [DOI] [PMID: 3539118] |
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| [EC 1.1.1.218 created 1989, modified 1990] |
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