| EC |
1.1.1.23 |
| Accepted name: |
histidinol dehydrogenase |
| Reaction: |
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+ |
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| Other name(s): |
L-histidinol dehydrogenase |
| Systematic name: |
L-histidinol:NAD+ oxidoreductase |
| Comments: |
Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-27-7 |
| References: |
| 1. |
Adams, E. Enzymatic synthesis of histidine from histidinol. J. Biol. Chem. 209 (1954) 829–846. [PMID: 13192138] |
| 2. |
Adams, E. L-Histidinal, a biosynthetic precursor of histidine. J. Biol. Chem. 217 (1955) 325–344. [PMID: 13271397] |
| 3. |
Loper, J.C. Histidinol dehydrogenase from Salmonella typhimurium. Crystallization and composition studies. J. Biol. Chem. 243 (1968) 3264–3272. [PMID: 4872177] |
| 4. |
Yourno, J. and Ino, I. Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2. J. Biol. Chem. 243 (1968) 3273–3276. [PMID: 4872176] |
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| [EC 1.1.1.23 created 1961] |
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