| EC |
1.1.1.231 |
| Accepted name: |
15-hydroxyprostaglandin-I dehydrogenase (NADP+) |
| Reaction: |
(5Z,13E)-(15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9α-epoxy-11α-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+ |
| Other name(s): |
prostacyclin dehydrogenase; PG I2 dehydrogenase; prostacyclin dehydrogenase; NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase; NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin-I dehydrogenase (NADP) |
| Systematic name: |
(5Z,13E)-(15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase |
| Comments: |
Specific for prostaglandin I2. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 79468-49-8 |
| References: |
| 1. |
Korff, J.M. and Jarabak, J. Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney. Methods Enzymol. 86 (1982) 152–155. [PMID: 6182444] |
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| [EC 1.1.1.231 created 1990] |
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