The Enzyme Database

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Accepted name: codeinone reductase (NADPH)
Reaction: codeine + NADP+ = codeinone + NADPH + H+
For diagram of morphine biosynthesis, click here
Systematic name: codeine:NADP+ oxidoreductase
Comments: Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 153302-41-1
1.  Lenz, R. and Zenk, M.H. Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum. Tetrahedron Lett. 36 (1995) 2449–2452.
2.  Lenz, R. and Zenk, M.H. Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures. Eur. J. Biochem. 233 (1995) 132–139. [DOI] [PMID: 7588736]
[EC created 1999, modified 2001]

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