The Enzyme Database

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Accepted name: galactitol-1-phosphate 5-dehydrogenase
Reaction: galactitol 1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+
Other name(s): gatD (gene name)
Systematic name: galactitol-1-phosphate:NAD+ oxidoreductase
Comments: The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway. It contains two zinc atoms per subunit.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 60120-43-6
1.  Wolff, J.B., Kaplan, N.O. Hexitol metabolism in Escherichia coli. J. Bacteriol. 71 (1956) 557–564. [PMID: 13331868]
2.  Nobelmann, B. and Lengeler, J.W. Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli. Biochim. Biophys. Acta 1262 (1995) 69–72. [DOI] [PMID: 7772602]
3.  Benavente, R., Esteban-Torres, M., Kohring, G.W., Cortes-Cabrera, A., Sanchez-Murcia, P.A., Gago, F., Acebron, I., de las Rivas, B., Munoz, R. and Mancheno, J.M. Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli. Acta Crystallogr. D Biol. Crystallogr. 71 (2015) 1540–1554. [DOI] [PMID: 26143925]
[EC created 1999]

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