EC |
1.1.1.252 |
Accepted name: |
tetrahydroxynaphthalene reductase |
Reaction: |
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ |
Systematic name: |
scytalone:NADP+ Δ5-oxidoreductase |
Comments: |
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141350-13-2 |
References: |
1. |
Wheeler, M.H. and Greenblatt, G.A. The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease. Exp. Mycol. 12 (1988) 151–160. |
2. |
Vidal-Cros, A., Viviani, F., Labesse, G., Boccara, M. and Gaudry, M. Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing. Eur. J. Biochem. 219 (1994) 985–992. [DOI] [PMID: 8112349] |
3. |
Thompson, J.E., Basarab, G.S., Andersson, A., Lindqvist, Y. and Jordan, D.B. Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism. Biochemistry 36 (1997) 1852–1860. [DOI] [PMID: 9048570] |
|
[EC 1.1.1.252 created 1992 as EC 1.3.1.50, transferred 1999 to EC 1.1.1.252] |
|
|
|
|