The Enzyme Database

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Accepted name: tetrahydroxynaphthalene reductase
Reaction: scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
Systematic name: scytalone:NADP+ Δ5-oxidoreductase
Comments: Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141350-13-2
1.  Wheeler, M.H. and Greenblatt, G.A. The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease. Exp. Mycol. 12 (1988) 151–160.
2.  Vidal-Cros, A., Viviani, F., Labesse, G., Boccara, M. and Gaudry, M. Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing. Eur. J. Biochem. 219 (1994) 985–992. [DOI] [PMID: 8112349]
3.  Thompson, J.E., Basarab, G.S., Andersson, A., Lindqvist, Y. and Jordan, D.B. Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism. Biochemistry 36 (1997) 1852–1860. [DOI] [PMID: 9048570]
[EC created 1992 as EC, transferred 1999 to EC]

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