| EC |
1.1.1.268 |
| Accepted name: |
2-(R)-hydroxypropyl-CoM dehydrogenase |
| Reaction: |
2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+ |
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For diagram of epoxide carboxylation, click here |
| Glossary: |
coenzyme M (CoM) = 2-sulfanylethane-1-sulfonate = 2-mercaptoethanesulfonate (deprecated) |
| Other name(s): |
2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase; 2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase |
| Systematic name: |
2-{[(2R)-2-hydroxypropyl]sulfanyl}ethane-1-sulfonate:NAD+ oxidoreductase |
| Comments: |
The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system (comprising EC 4.4.1.23 [2-hydroxypropyl-CoM lyase; component I], EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 244301-33-5 |
| References: |
| 1. |
Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation. Proc. Natl. Acad. Sci. USA 96 (1999) 8432–8437. [DOI] [PMID: 10411892] |
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| [EC 1.1.1.268 created 2001] |
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