| EC |
1.1.1.27 |
| Accepted name: |
L-lactate dehydrogenase |
| Reaction: |
(S)-lactate + NAD+ = pyruvate + NADH + H+ |
| Other name(s): |
lactic acid dehydrogenase; L(+)-nLDH; L-(+)-lactate dehydrogenase; L-lactic dehydrogenase; L-lactic acid dehydrogenase; lactate dehydrogenase; lactate dehydrogenase NAD-dependent; lactic dehydrogenase; NAD-lactate dehydrogenase |
| Systematic name: |
(S)-lactate:NAD+ oxidoreductase |
| Comments: |
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-60-9 |
| References: |
| 1. |
Dennis, D. and Kaplan, N.O. D and L-lactic acid dehydrogenase in Lactobacillus plantarum. J. Biol. Chem. 235 (1960) 810–818. [PMID: 13815938] |
| 2. |
Everse, J. and Kaplan, N.O. Lactate dehydrogenases: structure and function. Adv. Enzymol. Relat. Subj. Biochem. 37 (1973) 61–133. [DOI] [PMID: 4146647] |
| 3. |
Holbrook, J.J., Liljas, A., Steindel, S.J. and Rossmann, M.G. Lactate dehydrogenase. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 11, Academic Press, New York, 1975, pp. 191–292. |
| 4. |
Schär, H.-P. and Zuber, H. Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. I) Isolation and characterization of lactate dehydrogenases from thermophilic and mesophilic bacilli. Hoppe-Seyler's Z. Physiol. Chem. 360 (1979) 795–807. [PMID: 114469] |
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| [EC 1.1.1.27 created 1961] |
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