The Enzyme Database

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Accepted name: vellosimine dehydrogenase
Reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+
For diagram of geissoschizine and sarpagine biosynthesis, click here
Systematic name: 10-deoxysarpagine:NADP+ oxidoreductase
Comments: Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 86777-26-6
1.  Pfitzner, A., Krausch, B. and Stöckigt, J. Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine. Tetrahedron 40 (1984) 1691–1699.
[EC created 2002]

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