The Enzyme Database

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Accepted name: 3β-hydroxy-5β-steroid dehydrogenase
Reaction: 3β-hydroxy-5β-pregnane-20-one + NADP+ = 5β-pregnan-3,20-dione + NADPH + H+
For diagram of reaction, click here
Other name(s): 3β-hydroxysteroid 5β-oxidoreductase; 3β-hydroxysteroid 5β-progesterone oxidoreductase
Systematic name: 3β-hydroxy-5β-steroid:NADP+ 3-oxidoreductase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 162731-81-9
1.  Stuhlemmer, U. and Kreis, W. Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata. Plant Physiol. 34 (1996) 85–91.
2.  Seitz, H.U. and Gaertner, D.E. Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea. Plant Cell 38 (1994) 337–344.
3.  Lindemann, P. and Luckner, M. Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata. Phytochemistry 46 (1997) 507–513.
[EC created 2003]

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