ExplorEnz: EC 1.1.1.281

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1.1.1.281

Accepted name:

GDP-4-dehydro-6-deoxy-D-mannose reductase

Reaction:

GDP-α-D-rhamnose + NAD(P)⁺ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H⁺

For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here

Glossary:

GDP-α-D-rhamnose = GDP-6-deoxy-α-D-mannose
GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose

Other name(s):

GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous]; GDP-6-deoxy-D-lyxo-4-hexulose reductase; Rmd; GDP-6-deoxy-D-mannose:NAD(P)⁺ 4-oxidoreductase (D-rhamnose-forming); GDP-6-deoxy-α-D-mannose:NAD(P)⁺ 4-oxidoreductase (D-rhamnose-forming)

Systematic name:

GDP-α-D-rhamnose:NAD(P)⁺ 4-oxidoreductase

Comments:

This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-α-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Kneidinger, B., Graninger, M., Adam, G., Puchberger, M., Kosma, P., Zayni, S. and Messner, P. Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91^T. J. Biol. Chem. 276 (2001) 5577–5583. [DOI] [PMID: 11096116]
2.	Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Mattila, P. and Renkonen, R. Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose. Eur. J. Biochem. 269 (2002) 593–601. [DOI] [PMID: 11856318]

[EC 1.1.1.281 created 2004]