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Your query returned 1 entry. Printable version
EC | 1.1.1.286 | ||
Accepted name: | isocitrate—homoisocitrate dehydrogenase | ||
Reaction: | (1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH (2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ |
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Glossary: | isocitrate = (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate (previously known as threo-Ds-isocitrate) homoisocitrate = (-)-threo-homoisocitrate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
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Other name(s): | homoisocitrate—isocitrate dehydrogenase; PH1722 | ||
Systematic name: | isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) | ||
Comments: | Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
References: |
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