EC |
1.1.1.310 |
Accepted name: |
(S)-sulfolactate dehydrogenase |
Reaction: |
(2S)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+ |
Other name(s): |
(2S)-3-sulfolactate dehydrogenase; SlcC |
Systematic name: |
(2S)-sulfolactate:NAD+ oxidoreductase |
Comments: |
This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase.
The enzyme is specific for NAD+. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Denger, K. and Cook, A.M. Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase. Microbiology 156 (2010) 967–974. [DOI] [PMID: 20007648] |
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[EC 1.1.1.310 created 2011, modified 2013] |
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