The Enzyme Database

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Accepted name: (2R)-3-sulfolactate dehydrogenase (NADP+)
Reaction: (2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+
For diagram of coenzyme-M biosynthesis, click here
Other name(s): (R)-sulfolactate:NADP+ oxidoreductase; L-sulfolactate dehydrogenase; (R)-sulfolactate dehydrogenase; ComC
Systematic name: (2R)-3-sulfolactate:NADP+ oxidoreductase
Comments: The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 81210-65-3
1.  Denger, K. and Cook, A.M. Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase. Microbiology 156 (2010) 967–974. [DOI] [PMID: 20007648]
[EC created 2012]

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