The Enzyme Database

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Accepted name: hydroxymethylglutaryl-CoA reductase (NADPH)
Reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
For diagram of mevalonate biosynthesis, click here
Other name(s): hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous); β-hydroxy-β-methylglutaryl coenzyme A reductase (ambiguous); hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous); NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2)
Systematic name: (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
Comments: The enzyme is inactivated by EC {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-35-7
1.  Bucher, N.L.R., Overath, P. and Lynen, F. β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver. Biochim. Biophys. Acta 40 (1960) 491–501. [PMID: 13805544]
2.  Durr, I.F. and Rudney, H. The reduction of β-hydroxy-β-methylglutaryl coenzyme A to mevalonic acid. J. Biol. Chem. 235 (1960) 2572–2578. [PMID: 13818862]
3.  Kawachi, T. and Rudney, H. Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver. Biochemistry 9 (1970) 1700. [PMID: 4985697]
[EC created 1961]

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