ExplorEnz: EC 1.1.1.349

Your query returned 1 entry. Printable version

1.1.1.349

Accepted name:

norsolorinic acid ketoreductase

Reaction:

(1′S)-averantin + NADP⁺ = norsolorinic acid + NADPH + H⁺

Glossary:

norsolorinic acid = 2-hexanoyl-1,3,6,8-tetrahydroxy-9,10-anthraquinone
(1′S)-averantin = 1,3,6,8-tetrahydroxy-[(1S)-2-hydroxyhexyl]-9,10-anthraquinone

Other name(s):

aflD (gene name); nor-1 (gene name)

Systematic name:

(1′S)-averantin:NADP⁺ oxidoreductase

Comments:

Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Yabe, K., Matsuyama, Y., Ando, Y., Nakajima, H. and Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. Appl. Environ. Microbiol. 59 (1993) 2486–2492. [PMID: 8368836]
2.	Zhou, R. and Linz, J.E. Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Environ. Microbiol. 65 (1999) 5639–5641. [PMID: 10584035]

[EC 1.1.1.349 created 2013]