ExplorEnz: EC 1.1.1.352

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1.1.1.352

Accepted name:

5′-hydroxyaverantin dehydrogenase

Reaction:

(1) (1′S,5′S)-hydroxyaverantin + NAD⁺ = 5′-oxoaverantin + NADH + H⁺
(2) (1′S,5′R)-hydroxyaverantin + NAD⁺ = 5′-oxoaverantin + NADH + H⁺

Glossary:

5′-oxoaverantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione

Other name(s):

HAVN dehydrogenase; adhA (gene name)

Systematic name:

(1′S,5′S)-hydroxyaverantin:NAD⁺ oxidoreductase

Comments:

Isolated from the aflatoxin-producing mold Aspergillus parasiticus [2]. Involved in aflatoxin biosynthesis. 5′-Oxoaverantin will spontaneously form averufin by intramolecular ketalisation. cf. EC 4.2.1.142, 5′-oxoaverantin cyclase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Chang, P.K., Yu, J., Ehrlich, K.C., Boue, S.M., Montalbano, B.G., Bhatnagar, D. and Cleveland, T.E. adhA in Aspergillus parasiticus is involved in conversion of 5′-hydroxyaverantin to averufin. Appl. Environ. Microbiol. 66 (2000) 4715–4719. [DOI] [PMID: 11055914]
2.	Sakuno, E., Yabe, K. and Nakajima, H. Involvement of two cytosolic enzymes and a novel intermediate, 5′-oxoaverantin, in the pathway from 5′-hydroxyaverantin to averufin in aflatoxin biosynthesis. Appl. Environ. Microbiol. 69 (2003) 6418–6426. [DOI] [PMID: 14602595]

[EC 1.1.1.352 created 2013]