| EC |
1.1.1.358 |
| Accepted name: |
2-dehydropantolactone reductase |
| Reaction: |
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ |
| Other name(s): |
2-oxopantoyl lactone reductase; 2-ketopantoyl lactone reductase; ketopantoyl lactone reductase; 2-dehydropantoyl-lactone reductase |
| Systematic name: |
(R)-pantolactone:NADP+ oxidoreductase |
| Comments: |
The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Hata, H., Shimizu, S., Hattori, S. and Yamada, H. Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase. Biochim. Biophys. Acta 990 (1989) 175–181. [DOI] [PMID: 2644973] |
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| [EC 1.1.1.358 created 2013] |
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