ExplorEnz: EC 1.1.1.360

Your query returned 1 entry. Printable version

1.1.1.360

Accepted name:

glucose/galactose 1-dehydrogenase

Reaction:

(1) D-glucopyranose + NADP⁺ = D-glucono-1,5-lactone + NADPH + H⁺
(2) D-galactopyranose + NADP⁺ = D-galactono-1,5-lactone + NADPH + H⁺

For diagram of the Entner-Doudoroff Pathway, click here

Other name(s):

GdhA; dual-specific glucose/galactose dehydrogenase; glucose (galactose) dehydrogenase; glucose/galactose dehydrogenase

Systematic name:

D-glucose/D-galactose 1-dehydrogenase (NADPH)

Comments:

A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP⁺ compared to NAD⁺. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP⁺) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP⁺)).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Angelov, A., Futterer, O., Valerius, O., Braus, G.H. and Liebl, W. Properties of the recombinant glucose/galactose dehydrogenase from the extreme thermoacidophile, Picrophilus torridus. FEBS J. 272 (2005) 1054–1062. [DOI] [PMID: 15691337]
2.	Milburn, C.C., Lamble, H.J., Theodossis, A., Bull, S.D., Hough, D.W., Danson, M.J. and Taylor, G.L. The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. J. Biol. Chem. 281 (2006) 14796–14804. [DOI] [PMID: 16556607]

[EC 1.1.1.360 created 2013]