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Your query returned 1 entry. Printable version
EC | 1.1.1.362 | ||
Accepted name: | aklaviketone reductase | ||
Reaction: | aklavinone + NADP+ = aklaviketone + NADPH + H+ | ||
For diagram of aflatoxin biosynthesis, click here | |||
Glossary: | aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate |
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Other name(s): | dauE (gene name); aknU (gene name) | ||
Systematic name: | aklavinone:NADP+ oxidoreductase | ||
Comments: | The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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