ExplorEnz: EC 1.1.1.38

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1.1.1.38

Accepted name:

malate dehydrogenase (oxaloacetate-decarboxylating)

Reaction:

(1) (S)-malate + NAD⁺ = pyruvate + CO₂ + NADH
(2) oxaloacetate = pyruvate + CO₂

Other name(s):

’malic’ enzyme (ambiguous); pyruvic-malic carboxylase (ambiguous); NAD⁺-specific malic enzyme; NAD⁺-malic enzyme; NAD⁺-linked malic enzyme

Systematic name:

(S)-malate:NAD⁺ oxidoreductase (oxaloacetate-decarboxylating)

Comments:

Unlike EC 1.1.1.39, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC 1.1.1.40, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP⁺).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9080-52-8

References:

1.	Kaufman, S., Korkes, S. and del Campillo, A. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V. Further studies of the "malic" enzyme of Lactobacillus arabinosus. J. Biol. Chem. 192 (1951) 301–312. [PMID: 14917678]
2.	Yamaguchi, M. Studies on regulatory functions of malic enzymes. IV. Effects of sulfhydryl group modification on the catalytic function of NAD-linked malic enzyme from Escherichia coli. J. Biochem. 86 (1979) 325–333. [PMID: 225306]

[EC 1.1.1.38 created 1961]