ExplorEnz: EC 1.1.1.387

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1.1.1.387

Accepted name:

L-serine 3-dehydrogenase (NAD⁺)

Reaction:

L-serine + NAD⁺ = 2-aminoacetaldehyde + CO₂ + NADH + H⁺ (overall reaction)
(1a) L-serine + NAD⁺ = 2-aminomalonate semialdehyde + NADH + H⁺
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO₂ (spontaneous)

Other name(s):

NAD⁺-dependent L-serine dehydrogenase

Systematic name:

L-serine:NAD⁺ 3-oxidoreductase

Comments:

The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP⁺ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP⁺)].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Tchigvintsev, A., Singer, A., Brown, G., Flick, R., Evdokimova, E., Tan, K., Gonzalez, C.F., Savchenko, A. and Yakunin, A.F. Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD⁺-dependent L-serine dehydrogenase. J. Biol. Chem. 287 (2012) 1874–1883. [DOI] [PMID: 22128181]

[EC 1.1.1.387 created 2015]