EC |
1.1.1.393 |
Accepted name: |
3β-hydroxycholanate 3-dehydrogenase (NADP+) |
Reaction: |
isolithocholate + NADP+ = 3-oxo-5β-cholan-24-oate + NADPH + H+ |
Glossary: |
isolithocholate = 3β-hydroxy-5β-cholan-24-oate |
Other name(s): |
3β-hydroxysteroid dehydrogenase (ambiguous) |
Systematic name: |
isolithocholate:NADP+ 3-oxidoreductase |
Comments: |
This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3β-hydroxycholanate 3-dehydrogenase (NAD+). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Akao, T., Akao, T., Hattori, M., Namba, T. and Kobashi, K. 3 β-Hydroxysteroid dehydrogenase of Ruminococcus sp. from human intestinal bacteria. J. Biochem. 99 (1986) 1425–1431. [PMID: 3458705] |
2. |
Devlin, A.S. and Fischbach, M.A. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat. Chem. Biol. 11 (2015) 685–690. [DOI] [PMID: 26192599] |
|
[EC 1.1.1.393 created 2016] |
|
|
|
|