ExplorEnz: EC 1.1.1.397

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1.1.1.397

Accepted name:

β-methylindole-3-pyruvate reductase

Reaction:

(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD⁺ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H⁺

Glossary:

(R)-3-(indol-3-yl)-2-oxobutanoate = (R)-β-methylindole-3-pyruvate
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate = indolmycenate

Other name(s):

ind2 (gene name)

Systematic name:

(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD⁺ oxidoreductase

Comments:

The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan—tRNA ligase (EC 6.1.1.2).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Du, Y.L., Alkhalaf, L.M. and Ryan, K.S. In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly. Proc. Natl. Acad. Sci. USA 112 (2015) 2717–2722. [DOI] [PMID: 25730866]

[EC 1.1.1.397 created 2016]