ExplorEnz: EC 1.1.1.398

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1.1.1.398

Accepted name:

2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase

Reaction:

2-(glutathion-S-yl)-2-methylbut-3-en-1-ol + 2 NAD⁺ + H₂O = 2-(glutathion-S-yl)-2-methylbut-3-enoate + 2 NADH + 2 H⁺ (overall reaction)
(1a) 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol + NAD⁺ = 2-(glutathion-S-yl)-2-methylbut-3-enal + NADH + H⁺
(1b) 2-(glutathion-S-yl)-2-methylbut-3-enal + NAD⁺ + H₂O = 2-(glutathion-S-yl)-2-methylbut-3-enoate + NADH + H⁺

For diagram of isoprene biosynthesis and metabolism, click here

Other name(s):

isoH (gene name); 4-hydroxy-3-glutathionyl-3-methylbut-1-ene dehydrogenase

Systematic name:

2-(glutathion-S-yl)-2-methylbut-3-en-1-ol:NAD⁺ oxidoreductase

Comments:

The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	van Hylckama Vlieg, J.E., Kingma, J., Kruizinga, W. and Janssen, D.B. Purification of a glutathione S-transferase and a glutathione conjugate-specific dehydrogenase involved in isoprene metabolism in Rhodococcus sp. strain AD45. J. Bacteriol. 181 (1999) 2094–2101. [PMID: 10094686]

[EC 1.1.1.398 created 2016]