| EC |
1.1.1.398 |
| Accepted name: |
2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase |
| Reaction: |
2-(glutathion-S-yl)-2-methylbut-3-en-1-ol + 2 NAD+ + H2O = 2-(glutathion-S-yl)-2-methylbut-3-enoate + 2 NADH + 2 H+ (overall reaction)
(1a) 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol + NAD+ = 2-(glutathion-S-yl)-2-methylbut-3-enal + NADH + H+
(1b) 2-(glutathion-S-yl)-2-methylbut-3-enal + NAD+ + H2O = 2-(glutathion-S-yl)-2-methylbut-3-enoate + NADH + H+ |
| Other name(s): |
isoH (gene name); 4-hydroxy-3-glutathionyl-3-methylbut-1-ene dehydrogenase |
| Systematic name: |
2-(glutathion-S-yl)-2-methylbut-3-en-1-ol:NAD+ oxidoreductase |
| Comments: |
The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation. |
| References: |
| 1. |
van Hylckama Vlieg, J.E., Kingma, J., Kruizinga, W. and Janssen, D.B. Purification of a glutathione S-transferase and a glutathione conjugate-specific dehydrogenase involved in isoprene metabolism in Rhodococcus sp. strain AD45. J. Bacteriol. 181 (1999) 2094–2101. [PMID: 10094686] |
|
| [EC 1.1.1.398 created 2016] |
| |
|
| |
|