ExplorEnz: EC 1.1.1.402

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1.1.1.402

Accepted name:

D-erythritol 1-phosphate dehydrogenase

Reaction:

D-erythritol 1-phosphate + NADP⁺ = D-erythrulose 1-phosphate + NADPH + H⁺

Other name(s):

eryB (gene name)

Systematic name:

D-erythritol-1-phosphate 2-oxidoreductase

Comments:

The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Sperry, J.F. and Robertson, D.C. Erythritol catabolism by Brucella abortus. J. Bacteriol. 121 (1975) 619–630. [PMID: 163226]
2.	Sangari, F.J., Aguero, J. and Garcia-Lobo, J.M. The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus. Microbiology 146 (2000) 487–495. [DOI] [PMID: 10708387]
3.	Barbier, T., Collard, F., Zuniga-Ripa, A., Moriyon, I., Godard, T., Becker, J., Wittmann, C., Van Schaftingen, E. and Letesson, J.J. Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella. Proc. Natl. Acad. Sci. USA 111 (2014) 17815–17820. [DOI] [PMID: 25453104]

[EC 1.1.1.402 created 2016]