ExplorEnz: EC 1.1.1.409

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1.1.1.409

Accepted name:

4-phospho-D-erythronate 3-dehydrogenase

Reaction:

4-phospho-D-erythronate + NAD⁺ = glycerone phosphate + CO₂ + NADH + H⁺ (overall reaction)
(1a) 4-phospho-D-erythronate + NAD⁺ = 3-dehydro-4-phospho-L-threonate + NADH + H⁺
(1b) 3-dehydro-4-phospho-L-threonate = glycerone phosphate + CO₂ (spontaneous)

For diagram of erythronate and threonate catabolism, click here

Glossary:

D-erythronate = (2R,3R)-2,3,4-trihydroxybutanoate

Other name(s):

pdxA2 (gene name) (ambiguous)

Systematic name:

4-phospho-D-erythronate:NAD⁺ 3-oxidoreductase

Comments:

The enzyme, characterized from bacteria, is involved in a pathway for D-erythronate catabolism.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Zhang, X., Carter, M.S., Vetting, M.W., San Francisco, B., Zhao, S., Al-Obaidi, N.F., Solbiati, J.O., Thiaville, J.J., de Crecy-Lagard, V., Jacobson, M.P., Almo, S.C. and Gerlt, J.A. Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proc. Natl. Acad. Sci. USA 113 (2016) E4161–E4169. [DOI] [PMID: 27402745]

[EC 1.1.1.409 created 2017]