| EC |
1.1.1.418 |
| Accepted name: |
plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) |
| Reaction: |
a 3β-hydroxysteroid-4α-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH |
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For diagram of sterol ring A modification, click here |
| Other name(s): |
3β-HSD/D1 (gene name); 3β-HSD/D2 (gene name); 3β-hydroxysteroid dehydrogenases/C-4 decarboxylase (ambiguous) |
| Systematic name: |
3β-hydroxysteroid-4α-carboxylate:NAD+ 3-oxidoreductase (decarboxylating) |
| Comments: |
The enzyme, found in plants, catalyses multiple reactions during plant sterol biosynthesis. Unlike the fungal/animal enzyme EC 1.1.1.170, 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating), the plant enzyme is specific for NAD+. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 71822-23-6 |
| References: |
| 1. |
Rondet, S., Taton, M. and Rahier, A. Identification, characterization, and partial purification of 4 α-carboxysterol-C3-dehydrogenase/ C4-decarboxylase from Zea mays. Arch. Biochem. Biophys. 366 (1999) 249–260. [PMID: 10356290] |
| 2. |
Rahier, A., Darnet, S., Bouvier, F., Camara, B. and Bard, M. Molecular and enzymatic characterizations of novel bifunctional 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana. J. Biol. Chem. 281 (2006) 27264–27277. [PMID: 16835224] |
| 3. |
Rahier, A., Bergdoll, M., Genot, G., Bouvier, F. and Camara, B. Homology modeling and site-directed mutagenesis reveal catalytic key amino acids of 3β-hydroxysteroid-dehydrogenase/C4-decarboxylase from Arabidopsis. Plant Physiol. 149 (2009) 1872–1886. [PMID: 19218365] |
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| [EC 1.1.1.418 created 2019] |
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