ExplorEnz: EC 1.1.1.419

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1.1.1.419

Accepted name:

nepetalactol dehydrogenase

Reaction:

(1) (+)-cis,cis-nepetalactol + NAD⁺ = (+)-cis,cis-nepetalactone + NADH + H⁺
(2) (+)-cis,trans-nepetalactol + NAD⁺ = (+)-cis,trans-nepetalactone + NADH + H⁺

For diagram of secologanin biosynthesis, click here

Glossary:

(+)-cis,cis-nepetalactol = (4aR,7S,7aS)-4,7-dimethyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-ol
(+)-cis,trans-nepetalactol = (+)-iridodial lactol = (4aS,7S,7aR)-4,7-dimethyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-ol

Other name(s):

NEPS1 (gene name)

Systematic name:

nepetalactol:NAD⁺ 1-oxidoreductase

Comments:

The enzyme, characterized from the plant Nepeta mussinii, binds an NAD⁺ cofactor. It also catalyses the activity of EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Lichman, B.R., Kamileen, M.O., Titchiner, G.R., Saalbach, G., Stevenson, C.EM., Lawson, D.M. and O'Connor, S.E. Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis. Nat. Chem. Biol. 15 (2019) 71–79. [PMID: 30531909]
2.	Lichman, B.R., O'Connor, S.E. and Kries, H. Biocatalytic strategies towards [4+2] cycloadditions. Chemistry 25 (2019) 6864–6877. [PMID: 30664302]

[EC 1.1.1.419 created 2019]