ExplorEnz: EC 1.1.1.427

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1.1.1.427

Accepted name:

D-arabinose 1-dehydrogenase (NADP⁺)

Reaction:

D-arabinofuranose + NADP⁺ = D-arabinono-1,4-lactone + NADPH + H⁺

Other name(s):

AraDH; adh-4 (gene name)

Systematic name:

D-arabinose:NADP⁺ 1-oxidoreductase

Comments:

The enzyme from the archaeon Saccharolobus solfataricus is tetrameric and contains zinc. L-fucose also is a substrate. In contrast to EC 1.1.1.116 (D-arabinose 1-dehydrogenase (NAD⁺)) and EC 1.1.1.117 (D-arabinose 1-dehydrogenase [NAD(P)⁺]), this enzyme is specific for NADP⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Brouns, S.J., Walther, J., Snijders, A.P., van de Werken, H.J., Willemen, H.L., Worm, P., de Vos, M.G., Andersson, A., Lundgren, M., Mazon, H.F., van den Heuvel, R.H., Nilsson, P., Salmon, L., de Vos, W.M., Wright, P.C., Bernander, R. and van der Oost, J. Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment. J. Biol. Chem. 281 (2006) 27378–27388. [DOI] [PMID: 16849334]

Brouns, S.J., Turnbull, A.P., Willemen, H.L., Akerboom, J. and van der Oost, J. Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus. J. Mol. Biol. 371 (2007) 1249–1260. [DOI] [PMID: 17610898]

[EC 1.1.1.427 created 2022]