ExplorEnz: EC 1.1.1.441

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1.1.1.441

Accepted name:

polyprenol dehydrogenase [NAD(P)H]

Reaction:

(1) a ditrans,polycis-polyprenol + NAD(P)⁺ = a ditrans,polycis-polyprenal + NAD(P)H + H⁺
(2) a dolichol + NAD(P)⁺ = a dolichal + NAD(P)H + H⁺

Other name(s):

dolichal reductase; DHRSX (gene name)

Systematic name:

ditrans,polycis-polyprenol:NAD(P)⁺ oxidoreductase

Comments:

The enzyme, present in all eukaryotes, catalyses the dehydrogenation of ditrans,polycis-polyprenol and the reduction of dolichal as part of the pathway that converts ditrans,polycis-polyprenol to dolichol (cf. 1.3.1.94, polyprenal reductase). The enzyme works equally well with NAD⁺ and NADP⁺, but due to the cellular ratios of NAD⁺/NADH and NADP⁺/NADPH, the enzyme catalyses the oxidation of of polyprenol using NAD⁺ as the electron acceptor, and the reduction of dolichal using NADPH as the electron donor.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

Wilson, M.P., Kentache, T., Althoff, C.R., Schulz, C., de Bettignies, G., Mateu Cabrera, G., Cimbalistiene, L., Burnyte, B., Yoon, G., Costain, G., Vuillaumier-Barrot, S., Cheillan, D., Rymen, D., Rychtarova, L., Hansikova, H., Bury, M., Dewulf, J.P., Caligiore, F., Jaeken, J., Cantagrel, V., Van Schaftingen, E., Matthijs, G., Foulquier, F. and Bommer, G.T. A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis. Cell (2024) . [DOI] [PMID: 38821050]

[EC 1.1.1.441 created 2024]