| EC |
1.1.1.442 |
| Accepted name: |
20β-hydroxysteroid dehydrogenase |
| Reaction: |
20β-dihydrocortisol + NAD+ = cortisol + NADH + H+ |
| Other name(s): |
20β-HSDH; desE (gene name) |
| Systematic name: |
20β-dihydrocortisol:NAD+ 20-oxidoreductase |
| Comments: |
The enzyme, characterized from several gut bacteria, is specific for NADH and is much more active in the reductive direction. cf. the eukaryotic enzyme EC 1.1.1.53, 3α(or 20β)-hydroxysteroid dehydrogenase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Devendran, S., Mendez-Garcia, C. and Ridlon, J.M. Identification and characterization of a 20β-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058. J. Lipid Res. 58 (2017) 916–925. [DOI] [PMID: 28314858] |
| 2. |
Doden, H.L., Pollet, R.M., Mythen, S.M., Wawrzak, Z., Devendran, S., Cann, I., Koropatkin, N.M. and Ridlon, J.M. Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32. J. Biol. Chem. 294 (2019) 12040–12053. [DOI] [PMID: 31209107] |
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| [EC 1.1.1.442 created 2025] |
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