The Enzyme Database

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Accepted name: testosterone 17β-dehydrogenase (NADP+)
Reaction: testosterone + NADP+ = androstenedione + NADPH + H+
Glossary: androstenedione = androst-4-ene-3,17-dione
Other name(s): 17-ketoreductase; NADP-dependent testosterone-17β-oxidoreductase; testosterone 17β-dehydrogenase (NADP)
Systematic name: 17β-hydroxysteroid:NADP+ 17-oxidoreductase
Comments: Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-63-1
1.  Endahl, G.L., Kochakia, C.D. and Hamm, D. Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 2792–2796. [PMID: 13696735]
2.  Sweat, M.L., Samuels, L.T. and Lumry, R. Preparation and characterisation of the enzyme which converts testosterone to androstendione. J. Biol. Chem. 185 (1950) 75–84. [PMID: 15436478]
3.  Villee, C.A. and Spencer, J.M. Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 3615–3619. [PMID: 13781425]
[EC created 1965]

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