| EC |
1.1.1.78 |
| Accepted name: |
methylglyoxal reductase (NADH) |
| Reaction: |
(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+ |
| Glossary: |
2-oxopropanal = methylglyoxal |
| Other name(s): |
methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent) |
| Systematic name: |
(R)-lactaldehyde:NAD+ oxidoreductase |
| Comments: |
This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH), by its cosubstrate requirement, reaction direction, and enantiomeric preference. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37250-16-1 |
| References: |
| 1. |
Ting, S.-M., Miller, O.N. and Sellinger, O.Z. The metabolism of lactaldehyde. VII. The oxidation of D-lactaldehyde in rat liver. Biochim. Biophys. Acta 97 (1965) 407–415. [DOI] [PMID: 14323585] |
| 2. |
Ray, M. and Ray, S. Purification and partial characterization of a methylglyoxal reductase from goat liver. Biochim. Biophys. Acta 802 (1984) 119–127. [DOI] [PMID: 6386056] |
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| [EC 1.1.1.78 created 1972, modified 2005, modified 2013] |
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